biostudies-literatureUnknown7(1)Yamamotoya TThe Trk-fused gene (TFG) is reportedly involved in the process of COPII-mediated vesicle transport and missense mutations in TFG cause several neurodegenerative diseases including hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P). The high coincidence ratio between HMSN-P and diabetes mellitus suggests TFG to have an important role(s) in glucose homeostasis. To examine this possibility, β-cell specific TFG knockout mice (βTFG KO) were generated. Interestingly, βTFG KO displayed marked glucose intolerance with reduced insulin secretion. Immunohistochemical analysis revealed smaller β-cell masses in βTFG KO than in controls, likely attributable to diminished β-cell proliferation. Consistently, β-cell expansion in response to a high-fat, high-sucrose (HFHS) dScientific reports13026https://www.ebi.ac.uk/biostudies/studies/S-EPMC5638802biostudies-literatureTrk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.PMC5638802Ishihara HNakatsu YInoue MKSakoda HYamamotoya TUeda KMatsunaga YOno HAsano TKushiyama AFujishiro MInoue YKiyonari HfalseTrk-fused gene (TFG) regulates pancreatic β cell mass and insulin secretory activity.The Trk-fused gene (TFG) is reportedly involved in the process of COPII-mediated vesicle transport and missense mutations in TFG cause several neurodegenerative diseases including hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P). The high coincidence ratio between HMSN-P and diabetes mellitus suggests TFG to have an important role(s) in glucose homeostasis. To examine this possibility, β-cell specific TFG knockout mice (βTFG KO) were generated. Interestingly, βTFG KO displayed marked glucose intolerance with reduced insulin secretion. Immunohistochemical analysis revealed smaller β-cell masses in βTFG KO than in controls, likely attributable to diminished β-cell proliferation. Consistently, β-cell expansion in response to a high-fat, high-sucrose (HFHS) d2017-01-01T00:00:00Z2017 Oct2025-04-04T21:22:22.363Z2019-03-27T02:58:49ZS-EPMC56388022902615510.1038/s41598-017-13432-x