{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["81(4)"],"submitter":["Moon JY"],"pubmed_abstract":["A <i>Salmonella</i> Typhimurium ghost vaccine was constructed with the use of a recombinant fusion protein consisting of lysozyme and porcine myeloid antimicrobial peptide 36 expressed by the <i>Escherichia coli</i> overexpression system. After confirmation of its effectiveness by transmission electron microscopy the vaccine was evaluated in a murine model. Of the 60 BALB/c mice equally divided into 4 groups, group A mice were intramuscularly inoculated with 100 μL of sterile phosphate-buffered saline, and the mice in groups B, C, and D were intramuscularly inoculated with approximately 1.0 × 10<sup>4</sup>, 1.0 × 10<sup>5</sup>, or 1.0 × 10<sup>6</sup> cells of the <i>S.</i> Typhimurium ghost vaccine, respectively, in 100-μL amounts. The serum IgG titers against <i>S.</i> Typhimurium oute"],"journal":["Canadian journal of veterinary research = Revue canadienne de recherche veterinaire"],"pagination":["297-303"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5644453"],"repository":["biostudies-literature"],"pubmed_title":["Protective efficacy of a <i>Salmonella</i> Typhimurium ghost vaccine candidate constructed with a recombinant lysozyme-PMAP36 fusion protein in a murine model."],"pmcid":["PMC5644453"],"pubmed_authors":["Kim WK","Mun JY","Kim SY","Hur J","Kim B","Park JH","Moon JY","Choi HS","Rao Z"],"additional_accession":[]},"is_claimable":false,"name":"Protective efficacy of a <i>Salmonella</i> Typhimurium ghost vaccine candidate constructed with a recombinant lysozyme-PMAP36 fusion protein in a murine model.","description":"A <i>Salmonella</i> Typhimurium ghost vaccine was constructed with the use of a recombinant fusion protein consisting of lysozyme and porcine myeloid antimicrobial peptide 36 expressed by the <i>Escherichia coli</i> overexpression system. After confirmation of its effectiveness by transmission electron microscopy the vaccine was evaluated in a murine model. Of the 60 BALB/c mice equally divided into 4 groups, group A mice were intramuscularly inoculated with 100 μL of sterile phosphate-buffered saline, and the mice in groups B, C, and D were intramuscularly inoculated with approximately 1.0 × 10<sup>4</sup>, 1.0 × 10<sup>5</sup>, or 1.0 × 10<sup>6</sup> cells of the <i>S.</i> Typhimurium ghost vaccine, respectively, in 100-μL amounts. The serum IgG titers against <i>S.</i> Typhimurium oute","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-06-01T03:24:19.624Z","creation":"2021-02-20T02:02:22Z"},"accession":"S-EPMC5644453","cross_references":{"pubmed":["29081588"]}}