{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Daniloski Z"],"funding":["NCI NIH HHS","NIH","Department of Defense"],"pagination":["5530-5542"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5645240"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77(20)"],"pubmed_abstract":["Sister chromatids are held together by cohesin, a tripartite ring with a peripheral SA1/2 subunit, where SA1 is required for telomere cohesion and SA2 for centromere cohesion. The <i>STAG2</i> gene encoding SA2 is often inactivated in human cancer, but not in in a manner associated with aneuploidy. Thus, how these tumors maintain chromosomal cohesion and how <i>STAG2</i> loss contributes to tumorigenesis remain open questions. Here we show that, despite a loss in centromere cohesion, sister chromatids in <i>STAG2</i> mutant tumor cells maintain cohesion in mitosis at chromosome arms and telomeres. Telomere maintenance in <i>STAG2</i> mutant tumor cells occurred by either telomere recombination or telomerase activation mechanisms. Notably, these cells were refractory to telomerase inhibitor"],"journal":["Cancer research"],"pubmed_title":["Loss of Tumor Suppressor <i>STAG2</i> Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells."],"pmcid":["PMC5645240"],"funding_grant_id":["R01CA200751","W81XWH-16-1-0590","R01 CA200751"],"pubmed_authors":["Smith S","Daniloski Z"],"additional_accession":[]},"is_claimable":false,"name":"Loss of Tumor Suppressor <i>STAG2</i> Promotes Telomere Recombination and Extends the Replicative Lifespan of Normal Human Cells.","description":"Sister chromatids are held together by cohesin, a tripartite ring with a peripheral SA1/2 subunit, where SA1 is required for telomere cohesion and SA2 for centromere cohesion. The <i>STAG2</i> gene encoding SA2 is often inactivated in human cancer, but not in in a manner associated with aneuploidy. Thus, how these tumors maintain chromosomal cohesion and how <i>STAG2</i> loss contributes to tumorigenesis remain open questions. Here we show that, despite a loss in centromere cohesion, sister chromatids in <i>STAG2</i> mutant tumor cells maintain cohesion in mitosis at chromosome arms and telomeres. Telomere maintenance in <i>STAG2</i> mutant tumor cells occurred by either telomere recombination or telomerase activation mechanisms. Notably, these cells were refractory to telomerase inhibitor","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-04-03T23:54:18.432Z","creation":"2019-03-27T00:01:38Z"},"accession":"S-EPMC5645240","cross_references":{"pubmed":["28819029"],"doi":["10.1158/0008-5472.can-17-1260","10.1158/0008-5472.CAN-17-1260"]}}