{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Clements DR"],"funding":["Nova Scotia Health Research Foundation","Terry Fox Research Institute","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","Beatrice Hunter Cancer Research Institute","Wellcome Trust","Canadian Institutes of Health Research","Canadian Cancer Society Research Institute"],"pagination":["3391-3406"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5648240"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(9)"],"pubmed_abstract":["Myeloid cells play a central role in the context of viral eradication, yet precisely how these cells differentiate throughout the course of acute infections is poorly understood. In this study, we have developed a novel quantitative temporal in vivo proteomics (QTiPs) platform to capture proteomic signatures of temporally transitioning virus-driven myeloid cells directly in situ, thus taking into consideration host-virus interactions throughout the course of an infection. QTiPs, in combination with phenotypic, functional, and metabolic analyses, elucidated a pivotal role for inflammatory CD11b<sup>+</sup>, Ly6G<sup>-</sup>, Ly6C<sup>high-low</sup> cells in antiviral immune response and viral clearance. Most importantly, the time-resolved QTiPs data set showed the transition of CD11b<sup>+<"],"journal":["Journal of proteome research"],"pubmed_title":["Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages."],"pmcid":["PMC5648240"],"funding_grant_id":["108070/Z/15/Z","K01 DK098285"],"pubmed_authors":["Holay N","Gujar S","Kennedy BE","Sterea A","Weekes MP","Clements DR","Konda P","Sharif T","Almasi S","Lee PW","Helson E","Paulo JA","Gygi SP","Murphy JP","Kim Y"],"additional_accession":[]},"is_claimable":false,"name":"Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages.","description":"Myeloid cells play a central role in the context of viral eradication, yet precisely how these cells differentiate throughout the course of acute infections is poorly understood. In this study, we have developed a novel quantitative temporal in vivo proteomics (QTiPs) platform to capture proteomic signatures of temporally transitioning virus-driven myeloid cells directly in situ, thus taking into consideration host-virus interactions throughout the course of an infection. QTiPs, in combination with phenotypic, functional, and metabolic analyses, elucidated a pivotal role for inflammatory CD11b<sup>+</sup>, Ly6G<sup>-</sup>, Ly6C<sup>high-low</sup> cells in antiviral immune response and viral clearance. Most importantly, the time-resolved QTiPs data set showed the transition of CD11b<sup>+<","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2026-05-04T23:13:44.69Z","creation":"2026-04-07T21:03:20.213Z"},"accession":"S-EPMC5648240","cross_references":{"pubmed":["28768414"],"doi":["10.1021/acs.jproteome.7b00425"]}}