{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yuan J"],"funding":["Guizhou provincial fine-quality green branch specialized talents cultivation fund","Guizhou province department of a joint fund","The national natural science foundation of China","Guizhou province international technology cooperation plan"],"pagination":["314"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5648500"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["Background
Thymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but the effects of Tβ4 treatment on chronic renal tubular interstitial fibrosis (CRTIF) are poorly known. This study aimed to examine the effects of Tβ4 on the renal apoptosis and the expression of transforming growth factor (TGF-β), E-cadherin, and α-smooth muscle actin (α-SMA) in CRTIF rat models.Methods
Male SD rats were randomized into four groups (sham group, unilateral ureteral obstruction (UUO) group, UUO + low-dose Tβ4 group, and UUO + high-dose Tβ4 group). The pathological changes of kidney tissue and its function were assessed two weeks after UUO. In renal interstitial tissue,TGF-β, E-cadherin and α-SMA expres"],"journal":["BMC nephrology"],"pubmed_title":["Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models."],"pmcid":["PMC5648500"],"funding_grant_id":["81200539","201343","20137028","20147002"],"pubmed_authors":["Yang X","Tian M","Xie Y","Zha Y","Lin X","Shen Y","Zeng W","Yuan J","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Thymosin β4 alleviates renal fibrosis and tubular cell apoptosis through TGF-β pathway inhibition in UUO rat models.","description":"Background
Thymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but the effects of Tβ4 treatment on chronic renal tubular interstitial fibrosis (CRTIF) are poorly known. This study aimed to examine the effects of Tβ4 on the renal apoptosis and the expression of transforming growth factor (TGF-β), E-cadherin, and α-smooth muscle actin (α-SMA) in CRTIF rat models.Methods
Male SD rats were randomized into four groups (sham group, unilateral ureteral obstruction (UUO) group, UUO + low-dose Tβ4 group, and UUO + high-dose Tβ4 group). The pathological changes of kidney tissue and its function were assessed two weeks after UUO. In renal interstitial tissue,TGF-β, E-cadherin and α-SMA expres","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2026-07-09T10:24:07.854Z","creation":"2026-07-09T10:14:34.437Z"},"accession":"S-EPMC5648500","cross_references":{"pubmed":["29047363"],"doi":["10.1186/s12882-017-0708-1"]}}