biostudies-literatureGeno KAHHS | National Institutes of HealthNIA NIH HHSNIAID NIH HHSNHLBI NIH HHSNational Natural Science Foundation of China2775-2784https://www.ebi.ac.uk/biostudies/studies/S-EPMC5648713biostudies-literatureUnknown55(9)<i>Streptococcus pneumoniae</i> expresses capsular polysaccharides (CPSs) to protect itself from opsonophagocytic killing. The genes responsible for capsules synthesized by the Wzy-dependent mechanism, which accounts for 96 of the 98 known pneumococcal capsule types, are in a chromosomal region known as the <i>cps</i> locus. The nucleotide sequence in this region has been determined for all serotypes. In contrast, not all CPS structures have been defined. The structure of the serotype 35C polysaccharide was recently reported, but the presence of <i>O</i>-acetyltransferase genes in the serotype 35C <i>cps</i> locus suggested that it could be incomplete, as the reported structure contains no O-acetylation. In addition, the genetic distinction of serotype 35C from the closely related serotypeJournal of clinical microbiologyWciG <i>O</i>-Acetyltransferase Functionality Differentiates Pneumococcal Serotypes 35C and 42.PMC5648713R01 AG050607P01 HL10715331470003HHSN272201200005DT32 HL105346P01-HL-107153AG050607HL105346HHSN272201200005CBush CAWang MYang JGeno KANahm MHJin CfalseWciG <i>O</i>-Acetyltransferase Functionality Differentiates Pneumococcal Serotypes 35C and 42.<i>Streptococcus pneumoniae</i> expresses capsular polysaccharides (CPSs) to protect itself from opsonophagocytic killing. The genes responsible for capsules synthesized by the Wzy-dependent mechanism, which accounts for 96 of the 98 known pneumococcal capsule types, are in a chromosomal region known as the <i>cps</i> locus. The nucleotide sequence in this region has been determined for all serotypes. In contrast, not all CPS structures have been defined. The structure of the serotype 35C polysaccharide was recently reported, but the presence of <i>O</i>-acetyltransferase genes in the serotype 35C <i>cps</i> locus suggested that it could be incomplete, as the reported structure contains no O-acetylation. In addition, the genetic distinction of serotype 35C from the closely related serotype2017-01-01T00:00:00Z2017 Sep2026-05-04T23:17:18.407Z2026-04-07T21:02:42.249ZS-EPMC56487132865932310.1128/jcm.00822-1710.1128/JCM.00822-17