{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qin XY"],"funding":["Japan Agency for Medical Research and Development","RIKEN","Ministry of Education, Culture, Sports, Science and Technology"],"pagination":["257-266"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5652006"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24"],"pubmed_abstract":["The acute phase protein orosomucoid-1 (Orm1) is mainly expressed by hepatocytes (HPCs) under stress conditions. However, its specific function is not fully understood. Here, we report a role of Orm1 as an executer of HPC proliferation. Increases in serum levels of Orm1 were observed in patients after surgical resection for liver cancer and in mice undergone partial hepatectomy (PH). Transcriptome study showed that Orm1 became the most abundant in HPCs isolated from regenerating mouse liver tissues after PH. Both in vitro and in vivo siRNA-induced knockdown of Orm1 suppressed proliferation of mouse regenerating HPCs and human hepatic cells. Microarray analysis in regenerating mouse livers revealed that the signaling pathways controlling chromatin replication, especially the minichromosome maintenance protein complex genes were uniformly down-regulated following Orm1 knockdown. These data suggest that Orm1 is induced in response to hepatic injury and executes liver regeneration by activating cell cycle progression in HPCs."],"journal":["EBioMedicine"],"pubmed_title":["Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes."],"pmcid":["PMC5652006"],"funding_grant_id":["H24-B Drug Discovery-Hepatitis-General-003"],"pubmed_authors":["Kojima S","Furutani Y","Hayashizaki Y","Kokudo N","Lassmann T","Sone H","Kawaji H","Kikuchi J","Kawaguchi Y","Inoue I","Suzuki H","Matsuura T","Arner E","Carninci P","Tatsukawa H","Nagatsuma K","Wei F","Qin XY","Itoh M","Daub C","FANTOM consortium","Forrest ARR","Hara M"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes.","description":"The acute phase protein orosomucoid-1 (Orm1) is mainly expressed by hepatocytes (HPCs) under stress conditions. However, its specific function is not fully understood. Here, we report a role of Orm1 as an executer of HPC proliferation. Increases in serum levels of Orm1 were observed in patients after surgical resection for liver cancer and in mice undergone partial hepatectomy (PH). Transcriptome study showed that Orm1 became the most abundant in HPCs isolated from regenerating mouse liver tissues after PH. Both in vitro and in vivo siRNA-induced knockdown of Orm1 suppressed proliferation of mouse regenerating HPCs and human hepatic cells. Microarray analysis in regenerating mouse livers revealed that the signaling pathways controlling chromatin replication, especially the minichromosome maintenance protein complex genes were uniformly down-regulated following Orm1 knockdown. These data suggest that Orm1 is induced in response to hepatic injury and executes liver regeneration by activating cell cycle progression in HPCs.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2024-11-09T15:28:15.296Z","creation":"2019-03-27T02:59:38Z"},"accession":"S-EPMC5652006","cross_references":{"pubmed":["28927749"],"doi":["10.1016/j.ebiom.2017.09.008"]}}