biostudies-literatureFasching PANCI NIH HHS78133-78143https://www.ebi.ac.uk/biostudies/studies/S-EPMC5652844biostudies-literatureUnknown8(44)Hematotoxicity is one of the major side effects of chemotherapy. The aim of this study was to examine the association between single nucleotide polymorphisms (SNPs) and hematotoxicity in breast cancer patients in a subset of patients of the SUCCESS prospective phase III chemotherapy study. All patients (n = 1678) received three cycles of 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) followed by three cycles of docetaxel or docetaxel/gemcitabine, depending on randomization. Germline DNA was genotyped for 246 SNPs selected from a previous genome-wide association study (GWAS) in a panel of lymphoblastoid cell lines, with gemcitabine toxicity as the phenotype. All SNPs were tested for their value in predicting grade 3 or 4 neutropenic or leukopenic events (NLEs). Their prognostic valuOncotargetClinical validation of genetic variants associated with <i>in vitro</i> chemotherapy-related lymphoblastoid cell toxicity.PMC5652844N01 CA015083P30 CA015083P30 CA076292Rezai MJenkins GLichtenegger WEkici ABTesch HHeinrich GRack BRuebner MFridley BFehm TLux MPFasching PALi LWang LReis ABeckmann MWCunningham JMHaberle LJanni WWeinshilboum RMHein ASchneeweiss AfalseClinical validation of genetic variants associated with <i>in vitro</i> chemotherapy-related lymphoblastoid cell toxicity.Hematotoxicity is one of the major side effects of chemotherapy. The aim of this study was to examine the association between single nucleotide polymorphisms (SNPs) and hematotoxicity in breast cancer patients in a subset of patients of the SUCCESS prospective phase III chemotherapy study. All patients (n = 1678) received three cycles of 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) followed by three cycles of docetaxel or docetaxel/gemcitabine, depending on randomization. Germline DNA was genotyped for 246 SNPs selected from a previous genome-wide association study (GWAS) in a panel of lymphoblastoid cell lines, with gemcitabine toxicity as the phenotype. All SNPs were tested for their value in predicting grade 3 or 4 neutropenic or leukopenic events (NLEs). Their prognostic valu2017-01-01T00:00:00Z2017 Sep2026-04-29T09:55:52.233Z2019-03-27T02:59:42ZS-EPMC56528442910045510.18632/oncotarget.17726