{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Krawczyk KM"],"funding":["Governmental funding of Clinical Research within the National Health Service (ALF)","Faculty of Medicine at Lund University","The Marianne and Marcus Wallenberg Foundation","Vetenskapsrådet","SUS foundations and donations","National Association against Kidney Diseases","Malmö General Hospital Research Fund for cancer research","Professor Lars-Erik Gelins Commemorative fund","Cancerfonden","Strategic Cancer Research Program Biocare"],"pagination":["320"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5655893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["BACKGROUND:Caveolae are membrane invaginations measuring 50-100 nm. These organelles, composed of caveolin and cavin proteins, are important for cellular signaling and survival. Caveolae play incompletely defined roles in human kidneys. Induction of caveolin-1/CAV1 in diseased tubules has been described previously, but the responsible mechanism remains to be defined. METHODS:Healthy and atrophying human kidneys were stained for caveolar proteins, (caveolin 1-3 and cavin 1-4) and examined by electron microscopy. Induction of caveolar proteins was studied in isolated proximal tubules and primary renal epithelial cells. These cells were challenged with hypoxia or H2O2. Primary tubular cells were also subjected to viral overexpression of megakaryoblastic leukemia 1 (MKL1) and MKL1 inhibition b"],"journal":["BMC nephrology"],"pubmed_title":["Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1."],"pmcid":["PMC5655893"],"funding_grant_id":["K2015-65X-22662-01-3"],"pubmed_authors":["Nilsson H","Sward K","Johansson ME","Hansson J","Krawczyk KK","Krawczyk KM"],"additional_accession":[]},"is_claimable":false,"name":"Injury induced expression of caveolar proteins in human kidney tubules - role of megakaryoblastic leukemia 1.","description":"BACKGROUND:Caveolae are membrane invaginations measuring 50-100 nm. These organelles, composed of caveolin and cavin proteins, are important for cellular signaling and survival. Caveolae play incompletely defined roles in human kidneys. Induction of caveolin-1/CAV1 in diseased tubules has been described previously, but the responsible mechanism remains to be defined. METHODS:Healthy and atrophying human kidneys were stained for caveolar proteins, (caveolin 1-3 and cavin 1-4) and examined by electron microscopy. Induction of caveolar proteins was studied in isolated proximal tubules and primary renal epithelial cells. These cells were challenged with hypoxia or H2O2. Primary tubular cells were also subjected to viral overexpression of megakaryoblastic leukemia 1 (MKL1) and MKL1 inhibition b","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-04-27T03:57:20.436Z","creation":"2019-03-27T02:59:52Z"},"accession":"S-EPMC5655893","cross_references":{"pubmed":["29065889"],"doi":["10.1186/s12882-017-0738-8"]}}