{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zafar MU"],"funding":["NCATS NIH HHS"],"pagination":["e005120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5656402"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(8)"],"pubmed_abstract":["<h4>Background</h4>American College of Cardiology/American Heart Association guidelines advise waiting 5 to 7 days before operating on P2Y<sub>12</sub> inhibitor-treated acute coronary syndrome patients, to allow dissipation of its antiplatelet effects. Platelet transfusion is often used to restore hemostasis during operations, but its effectiveness and optimal timing are unclear. We investigated the degree of functional gains obtained from platelet supplementation after loading and maintenance of dual antiplatelet therapy with ticagrelor and the influence of timing on this strategy.<h4>Methods and results</h4>After baseline platelet testing (Multiplate Analyzer and VerifyNow), cardiovascular disease patients (n=20; 56.9±7.9 years; 65% men; 75% diabetic) received dual antiplatelet therapy "],"journal":["Circulation. Cardiovascular interventions"],"pubmed_title":["Impact of Timing on the Functional Recovery Achieved With Platelet Supplementation After Treatment With Ticagrelor."],"pmcid":["PMC5656402"],"funding_grant_id":["UL1 TR000067"],"pubmed_authors":["Baber U","Linares-Koloffon CA","Escolar G","Smith DA","Lam DW","Jimenez Britez G","Chen K","Sartori S","Zafar MU","Badimon JJ","Rey-Mendoza J","Fuster V"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Timing on the Functional Recovery Achieved With Platelet Supplementation After Treatment With Ticagrelor.","description":"<h4>Background</h4>American College of Cardiology/American Heart Association guidelines advise waiting 5 to 7 days before operating on P2Y<sub>12</sub> inhibitor-treated acute coronary syndrome patients, to allow dissipation of its antiplatelet effects. Platelet transfusion is often used to restore hemostasis during operations, but its effectiveness and optimal timing are unclear. We investigated the degree of functional gains obtained from platelet supplementation after loading and maintenance of dual antiplatelet therapy with ticagrelor and the influence of timing on this strategy.<h4>Methods and results</h4>After baseline platelet testing (Multiplate Analyzer and VerifyNow), cardiovascular disease patients (n=20; 56.9±7.9 years; 65% men; 75% diabetic) received dual antiplatelet therapy ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2026-05-04T23:52:53.267Z","creation":"2019-03-26T23:48:47Z"},"accession":"S-EPMC5656402","cross_references":{"pubmed":["28768756"],"doi":["10.1161/CIRCINTERVENTIONS.117.005120","10.1161/circinterventions.117.005120"]}}