{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fu W"],"funding":["Swiss National Science Foundation","Shanghai Institute of Higher Learning","Alexander von Humboldt-Stiftung","Dutch Research Council (NWO)"],"pagination":["e1701247"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5656418"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(10)"],"pubmed_abstract":["Over the past decade, the richness of electronic properties of graphene has attracted enormous interest for electrically detecting chemical and biological species using this two-dimensional material. However, the creation of practical graphene electronic sensors greatly depends on our ability to understand and maintain a low level of electronic noise, the fundamental reason limiting the sensor resolution. Conventionally, to reach the largest sensing response, graphene transistors are operated at the point of maximum transconductance, where 1/<i>f</i> noise is found to be unfavorably high and poses a major limitation in any attempt to further improve the device sensitivity. We show that operating a graphene transistor in an ambipolar mode near its neutrality point can markedly reduce the 1/<i>f</i> noise in graphene. Remarkably, our data reveal that this reduction in the electronic noise is achieved with uncompromised sensing response of the graphene chips and thus significantly improving the signal-to-noise ratio-compared to that of a conventionally operated graphene transistor for conductance measurement. As a proof-of-concept demonstration of the usage of the aforementioned new sensing scheme to a broader range of biochemical sensing applications, we selected an HIV-related DNA hybridization as the test bed and achieved detections at picomolar concentrations."],"journal":["Science advances"],"pubmed_title":["Biosensing near the neutrality point of graphene."],"pmcid":["PMC5656418"],"funding_grant_id":["award329521","154557","award329522","award329523","award329524","722.014.004","P300P2_154557","TP2016023"],"pubmed_authors":["Feng L","Offenhausser A","Fu W","Mayer D","Kireev D","Krause HJ","Panaitov G"],"additional_accession":[]},"is_claimable":false,"name":"Biosensing near the neutrality point of graphene.","description":"Over the past decade, the richness of electronic properties of graphene has attracted enormous interest for electrically detecting chemical and biological species using this two-dimensional material. However, the creation of practical graphene electronic sensors greatly depends on our ability to understand and maintain a low level of electronic noise, the fundamental reason limiting the sensor resolution. Conventionally, to reach the largest sensing response, graphene transistors are operated at the point of maximum transconductance, where 1/<i>f</i> noise is found to be unfavorably high and poses a major limitation in any attempt to further improve the device sensitivity. We show that operating a graphene transistor in an ambipolar mode near its neutrality point can markedly reduce the 1/<i>f</i> noise in graphene. Remarkably, our data reveal that this reduction in the electronic noise is achieved with uncompromised sensing response of the graphene chips and thus significantly improving the signal-to-noise ratio-compared to that of a conventionally operated graphene transistor for conductance measurement. As a proof-of-concept demonstration of the usage of the aforementioned new sensing scheme to a broader range of biochemical sensing applications, we selected an HIV-related DNA hybridization as the test bed and achieved detections at picomolar concentrations.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2026-05-05T22:34:17.158Z","creation":"2019-03-27T02:59:54Z"},"accession":"S-EPMC5656418","cross_references":{"pubmed":["29075669"],"doi":["10.1126/sciadv.1701247"]}}