biostudies-literatureUnknown8(48)Tong ZOsteoarthritis (OA) is the most commonly occurring degenerative joint disease worldwide, and its incidence has increased in recent years. We evaluated whether there is the association between MMP-3 and TIMP-3 variants and susceptibility to OA in a Chinese population. Venous blood samples were collected from 431 female participants (200 cases and 231 controls) at Hong Hui Hospital, Xi'an Jiaotong University College of Medicine between 2015 and 2016. After genotyping the samples using standard protocols, the association between MMP-3 and TIMP-3 single nucleotide polymorphisms and risk of OA was assessed by calculating odds ratios (ORs) and 95% confidence intervals (95% CIs) using unconditional logistic regression analysis. The minor G allele of rs650108 was associOncotarget83563-83569https://www.ebi.ac.uk/biostudies/studies/S-EPMC5663536biostudies-literatureAssociation between MMP3 and TIMP3 polymorphisms and risk of osteoarthritis.PMC5663536Liu YYan LTong ZChen BHao DfalseAssociation between MMP3 and TIMP3 polymorphisms and risk of osteoarthritis.Osteoarthritis (OA) is the most commonly occurring degenerative joint disease worldwide, and its incidence has increased in recent years. We evaluated whether there is the association between MMP-3 and TIMP-3 variants and susceptibility to OA in a Chinese population. Venous blood samples were collected from 431 female participants (200 cases and 231 controls) at Hong Hui Hospital, Xi'an Jiaotong University College of Medicine between 2015 and 2016. After genotyping the samples using standard protocols, the association between MMP-3 and TIMP-3 single nucleotide polymorphisms and risk of OA was assessed by calculating odds ratios (ORs) and 95% confidence intervals (95% CIs) using unconditional logistic regression analysis. The minor G allele of rs650108 was associ2017-01-01T00:00:00Z2017 Oct2025-04-04T14:10:21.8Z2019-03-27T03:00:26ZS-EPMC56635362913736410.18632/oncotarget.18745