biostudies-literatureZaglia TTelethonEuropean Research CouncilE9006-E9015https://www.ebi.ac.uk/biostudies/studies/S-EPMC5664523biostudies-literatureUnknown114(43)The mitochondrial Ca²⁺ uniporter complex (MCUC) is a multimeric ion channel which, by tuning Ca²⁺ influx into the mitochondrial matrix, finely regulates metabolic energy production. In the heart, this dynamic control of mitochondrial Ca²⁺ uptake is fundamental for cardiomyocytes to adapt to either physiologic or pathologic stresses. Mitochondrial calcium uniporter (MCU), which is the core channel subunit of MCUC, has been shown to play a critical role in the response to β-adrenoreceptor stimulation occurring during acute exercise. The molecular mechanisms underlying the regulation of MCU, in conditions requiring chronic increase in energy production, such as physiologic or pathologic cardiac growth, remain elusive. Here, we show that microRNA-1 (miR-1), a mProceedings of the National Academy of Sciences of the United States of AmericaContent of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy.PMC5664523294777GGP11224Ulrik WCerbai EFaggian GDe Stefani DSandri MPozzan TBorile GCeriotti PStellin GStolen TOVida VDi Lisa FCampo ACarullo PZaglia TCoppini RCatalucci DPrando VMongillo MArmani ARizzuto RfalseContent of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy.The mitochondrial Ca²⁺ uniporter complex (MCUC) is a multimeric ion channel which, by tuning Ca²⁺ influx into the mitochondrial matrix, finely regulates metabolic energy production. In the heart, this dynamic control of mitochondrial Ca²⁺ uptake is fundamental for cardiomyocytes to adapt to either physiologic or pathologic stresses. Mitochondrial calcium uniporter (MCU), which is the core channel subunit of MCUC, has been shown to play a critical role in the response to β-adrenoreceptor stimulation occurring during acute exercise. The molecular mechanisms underlying the regulation of MCU, in conditions requiring chronic increase in energy production, such as physiologic or pathologic cardiac growth, remain elusive. Here, we show that microRNA-1 (miR-1), a m2017-01-01T00:00:00Z2017 Oct2025-04-04T14:10:23.775Z2019-06-06T18:21:45ZS-EPMC56645232907309710.1073/pnas.1708772114