{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(15)"],"submitter":["Yang WW"],"pubmed_abstract":["Salivary adenoid cystic carcinoma (SACC) is a peculiar malignant tumor, characterized by its slow but inexorable growth, with a high incidence of lung metastasis and poor prognosis. Here, we show the upregulated expression of EGFR ligand epiregulin in a subset of SACC cells correlates with lung metastasis and unfavorable outcome in patients with SACC. We found that upregulation of epiregulin in SACC cells induced epithelial-mesenchymal transition by regulating GLI1/E-cadherin. Elevated epiregulin increased the expression of pro-angiogenic factors, such as VEGFA, bFGF, and IL-8. We also show that epiregulin can be delivered via exosomes and was enriched in exosomes derived from epiregulin-overexpressing SACC cells. Furthermore, treating immunodeficient mice with these epiregulin-enriched exosomes greatly enhanced SACC metastasis to lung. These epiregulin-enriched exosomes significantly enhanced angiogenesis in the neighboring tumor microenvironment and increased vascular permeability in the pre-metastatic lung microenvironment <i>in vivo</i>. Therefore, epiregulin, as well as epiregulin-containing exosomes, may be a novel target for controlling SACC lung metastasis."],"journal":["Theranostics"],"pagination":["3700-3714"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5667342"],"repository":["biostudies-literature"],"pubmed_title":["Epiregulin Promotes Lung Metastasis of Salivary Adenoid Cystic Carcinoma."],"pmcid":["PMC5667342"],"pubmed_authors":["Yang WW","Xu LH","Li SL","Ge XY","Fu J","Zhao F","Yang LQ","Chen CW"],"additional_accession":[]},"is_claimable":false,"name":"Epiregulin Promotes Lung Metastasis of Salivary Adenoid Cystic Carcinoma.","description":"Salivary adenoid cystic carcinoma (SACC) is a peculiar malignant tumor, characterized by its slow but inexorable growth, with a high incidence of lung metastasis and poor prognosis. Here, we show the upregulated expression of EGFR ligand epiregulin in a subset of SACC cells correlates with lung metastasis and unfavorable outcome in patients with SACC. We found that upregulation of epiregulin in SACC cells induced epithelial-mesenchymal transition by regulating GLI1/E-cadherin. Elevated epiregulin increased the expression of pro-angiogenic factors, such as VEGFA, bFGF, and IL-8. We also show that epiregulin can be delivered via exosomes and was enriched in exosomes derived from epiregulin-overexpressing SACC cells. Furthermore, treating immunodeficient mice with these epiregulin-enriched exosomes greatly enhanced SACC metastasis to lung. These epiregulin-enriched exosomes significantly enhanced angiogenesis in the neighboring tumor microenvironment and increased vascular permeability in the pre-metastatic lung microenvironment <i>in vivo</i>. Therefore, epiregulin, as well as epiregulin-containing exosomes, may be a novel target for controlling SACC lung metastasis.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-27T03:52:15.571Z","creation":"2019-03-27T03:00:41Z"},"accession":"S-EPMC5667342","cross_references":{"pubmed":["29109770"],"doi":["10.7150/thno.19712"]}}