{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(16)"],"submitter":["Huang CW"],"pubmed_abstract":["<h4>Purpose</h4>Growing evidence has demonstrated that aberrant expression of integrin α2β1 might contribute to the invasion, metastasis and drug resistance of non-small cell lung cancer (NSCLC). Thus, the integrin α2β1 targeting <sup>68</sup>Ga-DOTA-A2B1 tracer was validated in NSCLC in contrast to accumulation of the clinically used <sup>18</sup>F-FDG PET tracer to see if <sup>68</sup>Ga-DOTA-A2B1-PET imaging can offer a valuable and critical diagnostic imaging criterion for the identification of phenotypes of aggressive lung cancer.<h4>Methods</h4>To verify the prognostic value of integrin α2β1, several quantitative and functional <i>in vitro</i> assays were validated in different NSCLC cell lines (CL1-0, CL1-5, A549 and selected A549<sup>++</sup> cells). Positron emission tomography (P"],"journal":["Theranostics"],"pagination":["4013-4028"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5667422"],"repository":["biostudies-literature"],"pubmed_title":["The Use of PET Imaging for Prognostic Integrin α<sub>2</sub>β<sub>1</sub> Phenotyping to Detect Non-Small Cell Lung Cancer and Monitor Drug Resistance Responses."],"pmcid":["PMC5667422"],"pubmed_authors":["Hsu ST","Wu CP","Huang FT","Lin YH","Huang CW","Hsieh WC","Chiu H","Lin YW","Yen TC","Chung YH","Chang WC"],"additional_accession":[]},"is_claimable":false,"name":"The Use of PET Imaging for Prognostic Integrin α<sub>2</sub>β<sub>1</sub> Phenotyping to Detect Non-Small Cell Lung Cancer and Monitor Drug Resistance Responses.","description":"<h4>Purpose</h4>Growing evidence has demonstrated that aberrant expression of integrin α2β1 might contribute to the invasion, metastasis and drug resistance of non-small cell lung cancer (NSCLC). Thus, the integrin α2β1 targeting <sup>68</sup>Ga-DOTA-A2B1 tracer was validated in NSCLC in contrast to accumulation of the clinically used <sup>18</sup>F-FDG PET tracer to see if <sup>68</sup>Ga-DOTA-A2B1-PET imaging can offer a valuable and critical diagnostic imaging criterion for the identification of phenotypes of aggressive lung cancer.<h4>Methods</h4>To verify the prognostic value of integrin α2β1, several quantitative and functional <i>in vitro</i> assays were validated in different NSCLC cell lines (CL1-0, CL1-5, A549 and selected A549<sup>++</sup> cells). Positron emission tomography (P","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2026-04-16T07:11:12.069Z","creation":"2019-03-27T03:00:41Z"},"accession":"S-EPMC5667422","cross_references":{"pubmed":["29109795"],"doi":["10.7150/thno.19304"]}}