biostudies-literatureUnknown7(16)Huang CW<h4>Purpose</h4>Growing evidence has demonstrated that aberrant expression of integrin α2β1 might contribute to the invasion, metastasis and drug resistance of non-small cell lung cancer (NSCLC). Thus, the integrin α2β1 targeting ⁶⁸Ga-DOTA-A2B1 tracer was validated in NSCLC in contrast to accumulation of the clinically used ¹⁸F-FDG PET tracer to see if ⁶⁸Ga-DOTA-A2B1-PET imaging can offer a valuable and critical diagnostic imaging criterion for the identification of phenotypes of aggressive lung cancer.<h4>Methods</h4>To verify the prognostic value of integrin α2β1, several quantitative and functional <i>in vitro</i> assays were validated in different NSCLC cell lines (CL1-0, CL1-5, A549 and selected A549⁺⁺ cells). Positron emission tomography (PTheranostics4013-4028https://www.ebi.ac.uk/biostudies/studies/S-EPMC5667422biostudies-literatureThe Use of PET Imaging for Prognostic Integrin α₂β₁ Phenotyping to Detect Non-Small Cell Lung Cancer and Monitor Drug Resistance Responses.PMC5667422Hsu STWu CPHuang FTLin YHHuang CWHsieh WCChiu HLin YWYen TCChung YHChang WCfalseThe Use of PET Imaging for Prognostic Integrin α₂β₁ Phenotyping to Detect Non-Small Cell Lung Cancer and Monitor Drug Resistance Responses.<h4>Purpose</h4>Growing evidence has demonstrated that aberrant expression of integrin α2β1 might contribute to the invasion, metastasis and drug resistance of non-small cell lung cancer (NSCLC). Thus, the integrin α2β1 targeting ⁶⁸Ga-DOTA-A2B1 tracer was validated in NSCLC in contrast to accumulation of the clinically used ¹⁸F-FDG PET tracer to see if ⁶⁸Ga-DOTA-A2B1-PET imaging can offer a valuable and critical diagnostic imaging criterion for the identification of phenotypes of aggressive lung cancer.<h4>Methods</h4>To verify the prognostic value of integrin α2β1, several quantitative and functional <i>in vitro</i> assays were validated in different NSCLC cell lines (CL1-0, CL1-5, A549 and selected A549⁺⁺ cells). Positron emission tomography (P2017-01-01T00:00:00Z20172026-04-16T07:11:12.069Z2019-03-27T03:00:41ZS-EPMC56674222910979510.7150/thno.19304