{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(45)"],"submitter":["Jun M"],"pubmed_abstract":["<h4>Aims</h4>To investigate the association of several single nucleotide polymorphisms (SNPs) within Interleukin-6 (<i>IL- 6</i>) and vitamin D receptor (<i>VDR</i>) gene, and additional gene- gene and gene- smoking interaction with coronary heart disease (CHD) risk in a Chinese population.<h4>Methods</h4>Hardy-Weinberg equilibrium (HWE) examination was used by SNPstats (http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking. Stratified analysis for gene- smoking interaction was investigated by logistic regression.<h4>Results</h4>CHD risk was significantly higher in carriers with the C allele of rs1800796 within <i>IL-6</i> gene than those with GG genotype (GC+ CC versus GG"],"journal":["Oncotarget"],"pagination":["78419-78428"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5667972"],"repository":["biostudies-literature"],"pubmed_title":["Interactions between <i>vitamin D receptor</i> (<i>VDR</i>) gene and <i>Interleukin-6</i> gene and environment factors on coronary heart disease risk in a Chinese Han population."],"pmcid":["PMC5667972"],"pubmed_authors":["Xue-Qiang G","Jun M","Ge J","Yang-Jing X","Jia L","Cheng Z"],"additional_accession":[]},"is_claimable":false,"name":"Interactions between <i>vitamin D receptor</i> (<i>VDR</i>) gene and <i>Interleukin-6</i> gene and environment factors on coronary heart disease risk in a Chinese Han population.","description":"<h4>Aims</h4>To investigate the association of several single nucleotide polymorphisms (SNPs) within Interleukin-6 (<i>IL- 6</i>) and vitamin D receptor (<i>VDR</i>) gene, and additional gene- gene and gene- smoking interaction with coronary heart disease (CHD) risk in a Chinese population.<h4>Methods</h4>Hardy-Weinberg equilibrium (HWE) examination was used by SNPstats (http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking. Stratified analysis for gene- smoking interaction was investigated by logistic regression.<h4>Results</h4>CHD risk was significantly higher in carriers with the C allele of rs1800796 within <i>IL-6</i> gene than those with GG genotype (GC+ CC versus GG","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-06-01T12:02:01.094Z","creation":"2025-06-01T12:02:01.094Z"},"accession":"S-EPMC5667972","cross_references":{"pubmed":["29108239"],"doi":["10.18632/oncotarget.19472"]}}