biostudies-literatureUnknown8(45)Jun M<h4>Aims</h4>To investigate the association of several single nucleotide polymorphisms (SNPs) within Interleukin-6 (<i>IL- 6</i>) and vitamin D receptor (<i>VDR</i>) gene, and additional gene- gene and gene- smoking interaction with coronary heart disease (CHD) risk in a Chinese population.<h4>Methods</h4>Hardy-Weinberg equilibrium (HWE) examination was used by SNPstats (http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking. Stratified analysis for gene- smoking interaction was investigated by logistic regression.<h4>Results</h4>CHD risk was significantly higher in carriers with the C allele of rs1800796 within <i>IL-6</i> gene than those with GG genotype (GC+ CC versus GGOncotarget78419-78428https://www.ebi.ac.uk/biostudies/studies/S-EPMC5667972biostudies-literatureInteractions between <i>vitamin D receptor</i> (<i>VDR</i>) gene and <i>Interleukin-6</i> gene and environment factors on coronary heart disease risk in a Chinese Han population.PMC5667972Xue-Qiang GJun MGe JYang-Jing XJia LCheng ZfalseInteractions between <i>vitamin D receptor</i> (<i>VDR</i>) gene and <i>Interleukin-6</i> gene and environment factors on coronary heart disease risk in a Chinese Han population.<h4>Aims</h4>To investigate the association of several single nucleotide polymorphisms (SNPs) within Interleukin-6 (<i>IL- 6</i>) and vitamin D receptor (<i>VDR</i>) gene, and additional gene- gene and gene- smoking interaction with coronary heart disease (CHD) risk in a Chinese population.<h4>Methods</h4>Hardy-Weinberg equilibrium (HWE) examination was used by SNPstats (http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking. Stratified analysis for gene- smoking interaction was investigated by logistic regression.<h4>Results</h4>CHD risk was significantly higher in carriers with the C allele of rs1800796 within <i>IL-6</i> gene than those with GG genotype (GC+ CC versus GG2017-01-01T00:00:00Z2017 Oct2025-06-01T12:02:01.094Z2025-06-01T12:02:01.094ZS-EPMC56679722910823910.18632/oncotarget.19472