{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cuppini C"],"funding":["NICHD NIH HHS","NIMH NIH HHS","Ministero dell'Istruzione, dell'Università e della Ricerca","National Institute of Mental Health"],"pagination":["518"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5670153"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Failure to appropriately develop multisensory integration (MSI) of audiovisual speech may affect a child's ability to attain optimal communication. Studies have shown protracted development of MSI into late-childhood and identified deficits in MSI in children with an autism spectrum disorder (ASD). Currently, the neural basis of acquisition of this ability is not well understood. Here, we developed a computational model informed by neurophysiology to analyze possible mechanisms underlying MSI maturation, and its delayed development in ASD. The model posits that strengthening of feedforward and cross-sensory connections, responsible for the alignment of auditory and visual speech sound representations in posterior superior temporal gyrus/sulcus, can explain behavioral data on the acquisitio"],"journal":["Frontiers in human neuroscience"],"pubmed_title":["A Computational Analysis of Neural Mechanisms Underlying the Maturation of Multisensory Speech Integration in Neurotypical Children and Those on the Autism Spectrum."],"pmcid":["PMC5670153"],"funding_grant_id":["RO1MH085322","R01 MH085322","P30 HD071593","RBFR136E24"],"pubmed_authors":["Cuppini C","Ursino M","Magosso E","Ross LA","Molholm S","Foxe JJ"],"additional_accession":[]},"is_claimable":false,"name":"A Computational Analysis of Neural Mechanisms Underlying the Maturation of Multisensory Speech Integration in Neurotypical Children and Those on the Autism Spectrum.","description":"Failure to appropriately develop multisensory integration (MSI) of audiovisual speech may affect a child's ability to attain optimal communication. Studies have shown protracted development of MSI into late-childhood and identified deficits in MSI in children with an autism spectrum disorder (ASD). Currently, the neural basis of acquisition of this ability is not well understood. Here, we developed a computational model informed by neurophysiology to analyze possible mechanisms underlying MSI maturation, and its delayed development in ASD. The model posits that strengthening of feedforward and cross-sensory connections, responsible for the alignment of auditory and visual speech sound representations in posterior superior temporal gyrus/sulcus, can explain behavioral data on the acquisitio","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2026-07-15T21:18:14.325Z","creation":"2019-03-27T03:00:53Z"},"accession":"S-EPMC5670153","cross_references":{"pubmed":["29163099"],"doi":["10.3389/fnhum.2017.00518"]}}