{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Singh AK"],"funding":["DU-DST Pursue Grant","Council of Scientific and Industrial Research"],"pagination":["499-502"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5671431"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57(4)"],"pubmed_abstract":["Four (1, 2, 4 and 6) synthetic quaternary ammonium derivatives of pyranochromenones and (coumarinyloxy)acetamides were synthesized and investigated for their antimicrobial efficacy on MRSA (Methicillin-resistant Staphylococcus aureus), and multi-drug resistant Pseudomonas aeruginosa, Salmonella enteritidis and Mycobacterium tuberculosis H37Rv strain. One of the four compounds screened i.e. N,N,N-triethyl-10-((4,8,8-trimethyl-2-oxo-2,6,7,8-tetrahydropyrano[3,2-g]chromen-10-yl)oxy)decan-1-aminium bromide (1), demonstrated significant activity against S. aureus, P. aeruginosa and M. tuberculosis with MIC value of 16, 35, and 15.62 µg/ml respectively. The cytotoxicity evaluation of compound 1 on A549 cell lines showed it to be a safe antimicrobial molecule, TEM study suggested that the compoun"],"journal":["Indian journal of microbiology"],"pubmed_title":["Antimicrobial Efficacy of Synthetic Pyranochromenones and (Coumarinyloxy)acetamides."],"pmcid":["PMC5671431"],"funding_grant_id":["BSC 0302"],"pubmed_authors":["Singh AK","Sharma SK","Prasad S","Kamble SS","Kumar B","Gautam HK","Kumar S","Anand A"],"additional_accession":[]},"is_claimable":false,"name":"Antimicrobial Efficacy of Synthetic Pyranochromenones and (Coumarinyloxy)acetamides.","description":"Four (1, 2, 4 and 6) synthetic quaternary ammonium derivatives of pyranochromenones and (coumarinyloxy)acetamides were synthesized and investigated for their antimicrobial efficacy on MRSA (Methicillin-resistant Staphylococcus aureus), and multi-drug resistant Pseudomonas aeruginosa, Salmonella enteritidis and Mycobacterium tuberculosis H37Rv strain. One of the four compounds screened i.e. N,N,N-triethyl-10-((4,8,8-trimethyl-2-oxo-2,6,7,8-tetrahydropyrano[3,2-g]chromen-10-yl)oxy)decan-1-aminium bromide (1), demonstrated significant activity against S. aureus, P. aeruginosa and M. tuberculosis with MIC value of 16, 35, and 15.62 µg/ml respectively. The cytotoxicity evaluation of compound 1 on A549 cell lines showed it to be a safe antimicrobial molecule, TEM study suggested that the compoun","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2025-04-26T20:03:27.299Z","creation":"2019-03-27T00:09:07Z"},"accession":"S-EPMC5671431","cross_references":{"pubmed":["29151652"],"doi":["10.1007/s12088-017-0675-z"]}}