biostudies-literatureSingh AKDU-DST Pursue GrantCouncil of Scientific and Industrial Research499-502https://www.ebi.ac.uk/biostudies/studies/S-EPMC5671431biostudies-literatureUnknown57(4)Four (1, 2, 4 and 6) synthetic quaternary ammonium derivatives of pyranochromenones and (coumarinyloxy)acetamides were synthesized and investigated for their antimicrobial efficacy on MRSA (Methicillin-resistant Staphylococcus aureus), and multi-drug resistant Pseudomonas aeruginosa, Salmonella enteritidis and Mycobacterium tuberculosis H37Rv strain. One of the four compounds screened i.e. N,N,N-triethyl-10-((4,8,8-trimethyl-2-oxo-2,6,7,8-tetrahydropyrano[3,2-g]chromen-10-yl)oxy)decan-1-aminium bromide (1), demonstrated significant activity against S. aureus, P. aeruginosa and M. tuberculosis with MIC value of 16, 35, and 15.62 µg/ml respectively. The cytotoxicity evaluation of compound 1 on A549 cell lines showed it to be a safe antimicrobial molecule, TEM study suggested that the compounIndian journal of microbiologyAntimicrobial Efficacy of Synthetic Pyranochromenones and (Coumarinyloxy)acetamides.PMC5671431BSC 0302Singh AKSharma SKPrasad SKamble SSKumar BGautam HKKumar SAnand AfalseAntimicrobial Efficacy of Synthetic Pyranochromenones and (Coumarinyloxy)acetamides.Four (1, 2, 4 and 6) synthetic quaternary ammonium derivatives of pyranochromenones and (coumarinyloxy)acetamides were synthesized and investigated for their antimicrobial efficacy on MRSA (Methicillin-resistant Staphylococcus aureus), and multi-drug resistant Pseudomonas aeruginosa, Salmonella enteritidis and Mycobacterium tuberculosis H37Rv strain. One of the four compounds screened i.e. N,N,N-triethyl-10-((4,8,8-trimethyl-2-oxo-2,6,7,8-tetrahydropyrano[3,2-g]chromen-10-yl)oxy)decan-1-aminium bromide (1), demonstrated significant activity against S. aureus, P. aeruginosa and M. tuberculosis with MIC value of 16, 35, and 15.62 µg/ml respectively. The cytotoxicity evaluation of compound 1 on A549 cell lines showed it to be a safe antimicrobial molecule, TEM study suggested that the compoun2017-01-01T00:00:00Z2017 Dec2025-04-26T20:03:27.299Z2019-03-27T00:09:07ZS-EPMC56714312915165210.1007/s12088-017-0675-z