biostudies-literatureUnknown8Bouhouche ADuring the last two decades, 15 different genes have been reported to be responsible for the monogenic form of Parkinson's disease (PD), representing a worldwide frequency of 5-10%. Among them, 10 genes have been associated with autosomal recessive PD, with <i>PRKN</i> and <i>PINK1</i> being the most frequent. In a cohort of 145 unrelated Moroccan PD patients enrolled since 2013, 19 patients were born from a consanguineous marriage, of which 15 were isolated cases and 4 familial. One patient was homozygous for the common <i>LRRK2</i> G2019S mutation and the 18 others who did not carry this mutation were screened for exon rearrangements in the <i>PRKN</i> gene using Affymetrix Cytoscan HD microarray. Two patients were determined homozygous for <i>PRKN</i> exon-deletions, while another patieFrontiers in neurology567https://www.ebi.ac.uk/biostudies/studies/S-EPMC5674924biostudies-literatureMutation Analysis of Consanguineous Moroccan Patients with Parkinson's Disease Combining Microarray and Gene Panel.PMC5674924Regragui WSouirti ZRahmani MBrice ABouslam NBen El Haj RLesage STesson CTibar HYahyaoui MBouhouche ADrouet VBenomar AfalseMutation Analysis of Consanguineous Moroccan Patients with Parkinson's Disease Combining Microarray and Gene Panel.During the last two decades, 15 different genes have been reported to be responsible for the monogenic form of Parkinson's disease (PD), representing a worldwide frequency of 5-10%. Among them, 10 genes have been associated with autosomal recessive PD, with <i>PRKN</i> and <i>PINK1</i> being the most frequent. In a cohort of 145 unrelated Moroccan PD patients enrolled since 2013, 19 patients were born from a consanguineous marriage, of which 15 were isolated cases and 4 familial. One patient was homozygous for the common <i>LRRK2</i> G2019S mutation and the 18 others who did not carry this mutation were screened for exon rearrangements in the <i>PRKN</i> gene using Affymetrix Cytoscan HD microarray. Two patients were determined homozygous for <i>PRKN</i> exon-deletions, while another patie2017-01-01T00:00:00Z20172026-04-07T14:36:30.544Z2019-03-27T03:01:05ZS-EPMC56749242916333310.3389/fneur.2017.00567