{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(2)"],"submitter":["Zimmerman D"],"funding":["Rosas Fellowship"],"pubmed_abstract":["While many blood substitutes are based on mammalian hemoglobins (e.g., human hemoglobin, HbA), the naturally extracellular hemoglobins of invertebrates (a.k.a. erythrocruorins, Ecs) are intriguing alternative oxygen carriers. Specifically, the erythrocruorin of <i>Lumbricus terrestris</i> has been shown to effectively deliver oxygen in mice and rats without the negative side effects observed with HbA. In this study, the properties of six oligochaete Ecs (<i>Lumbricus terrestris</i>, <i>Eisenia hortensis</i>, <i>Eisenia fetida</i>, <i>Eisenia veneta</i>, <i>Eudrilus eugeniae</i>, and <i>Amynthas gracilis</i>) were compared in vitro to identify the most promising blood substitute candidate(s). Several metrics were used to compare the Ecs, including their oxidation rates, dissociation at phys"],"journal":["Bioengineering & translational medicine"],"pagination":["212-221"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5675092"],"repository":["biostudies-literature"],"pubmed_title":["Direct comparison of oligochaete erythrocruorins as potential blood substitutes."],"pmcid":["PMC5675092"],"pubmed_authors":["Abdulmalik O","Dienes J","Zimmerman D","Elmer JJ","DiIusto M"],"additional_accession":[]},"is_claimable":false,"name":"Direct comparison of oligochaete erythrocruorins as potential blood substitutes.","description":"While many blood substitutes are based on mammalian hemoglobins (e.g., human hemoglobin, HbA), the naturally extracellular hemoglobins of invertebrates (a.k.a. erythrocruorins, Ecs) are intriguing alternative oxygen carriers. Specifically, the erythrocruorin of <i>Lumbricus terrestris</i> has been shown to effectively deliver oxygen in mice and rats without the negative side effects observed with HbA. In this study, the properties of six oligochaete Ecs (<i>Lumbricus terrestris</i>, <i>Eisenia hortensis</i>, <i>Eisenia fetida</i>, <i>Eisenia veneta</i>, <i>Eudrilus eugeniae</i>, and <i>Amynthas gracilis</i>) were compared in vitro to identify the most promising blood substitute candidate(s). Several metrics were used to compare the Ecs, including their oxidation rates, dissociation at phys","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Jun","modification":"2026-04-16T09:24:30.36Z","creation":"2019-03-27T03:01:06Z"},"accession":"S-EPMC5675092","cross_references":{"pubmed":["29313031"],"doi":["10.1002/btm2.10067"]}}