{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Dominguez-Soto A"],"pubmed_abstract":["Peripheral serotonin (5-hydroxytryptamine, 5-HT) regulates cell growth and differentiation in numerous cell types through engagement of seven types of cell surface receptors (HTR1-7). Deregulated 5-HT/HTR levels contribute to pathology in chronic inflammatory diseases, with macrophages being relevant targets for the physio-pathological effects of 5-HT. In fact, 5-HT skews human macrophage polarization through engagement of 5-HT2BR and 5-HT7R receptors. We now report that 5-HT primes macrophages for reduced pro-inflammatory cytokine production and IFN type I-mediated signaling, and promotes an anti-inflammatory and pro-fibrotic gene signature in human macrophages. The acquisition of the 5-HT-dependent gene profile primarily depends on the 5-HT7R receptor and 5-HT7R-initiated PKA-dependent s"],"journal":["Scientific reports"],"pagination":["14761"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5676747"],"repository":["biostudies-literature"],"pubmed_title":["Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis."],"pmcid":["PMC5676747"],"pubmed_authors":["Nieto C","Vega MA","Simon-Fuentes M","Cuevas VD","Usategui A","Luis Pablos J","Casas-Engel ML","Corbi AL","Dominguez-Soto A"],"additional_accession":[]},"is_claimable":false,"name":"Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis.","description":"Peripheral serotonin (5-hydroxytryptamine, 5-HT) regulates cell growth and differentiation in numerous cell types through engagement of seven types of cell surface receptors (HTR1-7). Deregulated 5-HT/HTR levels contribute to pathology in chronic inflammatory diseases, with macrophages being relevant targets for the physio-pathological effects of 5-HT. In fact, 5-HT skews human macrophage polarization through engagement of 5-HT2BR and 5-HT7R receptors. We now report that 5-HT primes macrophages for reduced pro-inflammatory cytokine production and IFN type I-mediated signaling, and promotes an anti-inflammatory and pro-fibrotic gene signature in human macrophages. The acquisition of the 5-HT-dependent gene profile primarily depends on the 5-HT7R receptor and 5-HT7R-initiated PKA-dependent s","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Nov","modification":"2026-04-29T12:55:06.865Z","creation":"2019-03-27T03:01:11Z"},"accession":"S-EPMC5676747","cross_references":{"pubmed":["29116249"],"doi":["10.1038/s41598-017-15348-y"]}}