{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Saladino R"],"pubmed_abstract":["The formation of nucleosides in abiotic conditions is a major hurdle in origin-of-life studies. We have determined the pathway of a general reaction leading to the one-pot synthesis of ribo- and 2'-deoxy-ribonucleosides from sugars and purine nucleobases under proton irradiation in the presence of a chondrite meteorite. These conditions simulate the presumptive conditions in space or on an early Earth fluxed by slow protons from the solar wind, potentially mimicking a plausible prebiotic scenario. The reaction (i) requires neither pre-activated precursors nor intermediate purification/concentration steps, (ii) is based on a defined radical mechanism, and (iii) is characterized by stereoselectivity, regioselectivity and (poly)glycosylation. The yield is enhanced by formamide and meteorite r"],"journal":["Scientific reports"],"pagination":["14709"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5677017"],"repository":["biostudies-literature"],"pubmed_title":["Proton irradiation: a key to the challenge of N-glycosidic bond formation in a prebiotic context."],"pmcid":["PMC5677017"],"pubmed_authors":["Bizzarri BM","Saladino R","Jaber M","Timoshenko GN","Timperio AM","Krasavin E","Sponer JE","Sponer J","Georgelin T","Mauro ED","Rozanov A","Rigaud B","Botta L","Kapralov M"],"additional_accession":[]},"is_claimable":false,"name":"Proton irradiation: a key to the challenge of N-glycosidic bond formation in a prebiotic context.","description":"The formation of nucleosides in abiotic conditions is a major hurdle in origin-of-life studies. We have determined the pathway of a general reaction leading to the one-pot synthesis of ribo- and 2'-deoxy-ribonucleosides from sugars and purine nucleobases under proton irradiation in the presence of a chondrite meteorite. These conditions simulate the presumptive conditions in space or on an early Earth fluxed by slow protons from the solar wind, potentially mimicking a plausible prebiotic scenario. The reaction (i) requires neither pre-activated precursors nor intermediate purification/concentration steps, (ii) is based on a defined radical mechanism, and (iii) is characterized by stereoselectivity, regioselectivity and (poly)glycosylation. The yield is enhanced by formamide and meteorite r","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Nov","modification":"2025-05-31T22:50:34.123Z","creation":"2025-05-31T22:50:34.123Z"},"accession":"S-EPMC5677017","cross_references":{"pubmed":["29116184"],"doi":["10.1038/s41598-017-15392-8"]}}