{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bozler J"],"funding":["Defense Advanced Research Projects Agency","NICHD NIH HHS","NIMH NIH HHS","National Institutes of Health","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["e1007054"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5679645"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(10)"],"pubmed_abstract":["The ability to integrate experiential information and recall it in the form of memory is observed in a wide range of taxa, and is a hallmark of highly derived nervous systems. Storage of past experiences is critical for adaptive behaviors that anticipate both adverse and positive environmental factors. The process of memory formation and consolidation involve many synchronized biological events including gene transcription, protein modification, and intracellular trafficking: However, many of these molecular mechanisms remain illusive. With Drosophila as a model system we use a nonassociative memory paradigm and a systems level approach to uncover novel transcriptional patterns. RNA sequencing of Drosophila heads during and after memory formation identified a number of novel memory genes. "],"journal":["PLoS genetics"],"pubmed_title":["A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes."],"pmcid":["PMC5679645"],"funding_grant_id":["P01HD078253","HR0011-15-1-0002","R01 HD049116","1DP1MH110234","T32 GM008704","P01 HD078253","DP1 MH110234"],"pubmed_authors":["Theurkauf WE","Bosco G","Bozler J","Kacsoh BZ","Weng Z","Chen H"],"additional_accession":[]},"is_claimable":false,"name":"A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes.","description":"The ability to integrate experiential information and recall it in the form of memory is observed in a wide range of taxa, and is a hallmark of highly derived nervous systems. Storage of past experiences is critical for adaptive behaviors that anticipate both adverse and positive environmental factors. The process of memory formation and consolidation involve many synchronized biological events including gene transcription, protein modification, and intracellular trafficking: However, many of these molecular mechanisms remain illusive. With Drosophila as a model system we use a nonassociative memory paradigm and a systems level approach to uncover novel transcriptional patterns. RNA sequencing of Drosophila heads during and after memory formation identified a number of novel memory genes. ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2026-07-08T03:17:30.252Z","creation":"2019-03-27T03:01:25Z"},"accession":"S-EPMC5679645","cross_references":{"pubmed":["29084214"],"doi":["10.1371/journal.pgen.1007054"]}}