{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(1)"],"submitter":["Rathore SS"],"pubmed_abstract":["Cryptococcus neoformans infection is quite complex with both host-pathogen interaction and host immune profile determining disease progress and therapeutic outcome. Hence in the present study, the potential utility of (E)-5-benzylidenedihydrofuran-2(3 H)-one (compound-6) was explored as an effective anticryptococcal compound with immunomodulatory potential. The efficacy of compound-6 in pulmonary cryptococosis model using H99 strain was investigated. The effective dose was found to provide 100% survival, with a significant reduction of yeast burden in lungs and brain. The biodistribution analysis provided evidence for the presence of higher concentration of compound-6 in major organs including lungs and brain. In addition, compound-6 treated mice had significantly higher expression of IL-6"],"journal":["Scientific reports"],"pagination":["15400"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5684196"],"repository":["biostudies-literature"],"pubmed_title":["Exploration of Antifungal and Immunomodulatory Potentials of a Furanone Derivative to Rescue Disseminated Cryptococosis in Mice."],"pmcid":["PMC5684196"],"pubmed_authors":["Rathore SS","Cheepurupalli L","Ramakrishnan J","Isravel M","Raman T","Vellaisamy S","Chellappan DR"],"additional_accession":[]},"is_claimable":false,"name":"Exploration of Antifungal and Immunomodulatory Potentials of a Furanone Derivative to Rescue Disseminated Cryptococosis in Mice.","description":"Cryptococcus neoformans infection is quite complex with both host-pathogen interaction and host immune profile determining disease progress and therapeutic outcome. Hence in the present study, the potential utility of (E)-5-benzylidenedihydrofuran-2(3 H)-one (compound-6) was explored as an effective anticryptococcal compound with immunomodulatory potential. The efficacy of compound-6 in pulmonary cryptococosis model using H99 strain was investigated. The effective dose was found to provide 100% survival, with a significant reduction of yeast burden in lungs and brain. The biodistribution analysis provided evidence for the presence of higher concentration of compound-6 in major organs including lungs and brain. In addition, compound-6 treated mice had significantly higher expression of IL-6","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Nov","modification":"2025-04-18T19:02:53.955Z","creation":"2019-03-27T03:01:45Z"},"accession":"S-EPMC5684196","cross_references":{"pubmed":["29133871"],"doi":["10.1038/s41598-017-15500-8"]}}