{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(52)"],"submitter":["Cha YJ"],"pubmed_abstract":["<h4>Background</h4>Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal neoplasms that are composed of myofibroblastic cells accompanied by inflammatory infiltrate. We investigated the immune profiles of IMTs, including PD-L1 expression and proportion of CD8+ tumor-infiltrating lymphocytes (TILs), as well as its clinicopathological characteristics according to <i>ALK</i> gene rearrangementstatus.<h4>Methods</h4>Twenty-eight IMTs from 25 patients were retrieved from our pathology files (2005-2015), and their clinicopathological parameters and outcomes were analyzed. Immunohistochemistry (IHC) was performed using whole-tissue sections to detect PD-L1 and CD8 expression, and fluorescent in situ hybridization (FISH) analysis and IHC were performed using tissue microarrays to identif"],"journal":["Oncotarget"],"pagination":["89465-89474"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5685684"],"repository":["biostudies-literature"],"pubmed_title":["PD-L1 expression and CD8+ tumor-infiltrating lymphocytes are associated with ALK rearrangement and clinicopathological features in inflammatory myofibroblastic tumors."],"pmcid":["PMC5685684"],"pubmed_authors":["Shim HS","Cha YJ"],"additional_accession":[]},"is_claimable":false,"name":"PD-L1 expression and CD8+ tumor-infiltrating lymphocytes are associated with ALK rearrangement and clinicopathological features in inflammatory myofibroblastic tumors.","description":"<h4>Background</h4>Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal neoplasms that are composed of myofibroblastic cells accompanied by inflammatory infiltrate. We investigated the immune profiles of IMTs, including PD-L1 expression and proportion of CD8+ tumor-infiltrating lymphocytes (TILs), as well as its clinicopathological characteristics according to <i>ALK</i> gene rearrangementstatus.<h4>Methods</h4>Twenty-eight IMTs from 25 patients were retrieved from our pathology files (2005-2015), and their clinicopathological parameters and outcomes were analyzed. Immunohistochemistry (IHC) was performed using whole-tissue sections to detect PD-L1 and CD8 expression, and fluorescent in situ hybridization (FISH) analysis and IHC were performed using tissue microarrays to identif","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-04-22T21:19:22.879Z","creation":"2019-03-27T03:01:51Z"},"accession":"S-EPMC5685684","cross_references":{"pubmed":["29163763"],"doi":["10.18632/oncotarget.20948"]}}