{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Salem ME"],"funding":["NCI NIH HHS"],"pagination":["86356-86368"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5689690"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(49)"],"pubmed_abstract":["Tumor sidedness has emerged as an important prognostic and predictive factor in the treatment of colorectal cancer. Recent studies demonstrate that patients with advanced right-sided colon cancers have a worse prognosis than those with left-sided colon or rectal cancers, and these patient subgroups respond differently to biological therapies. Historically, management of patients with metastatic colon and rectal cancers has been similar, and colon and rectal cancer patients have been grouped together in large clinical trials. Clearly, the differences in molecular biology among right-sided colon, left-sided colon, and rectal cancers should be further studied in order to account for disparities in clinical outcomes. We profiled 10,570 colorectal tumors (of which 2,413 were identified as arisi"],"journal":["Oncotarget"],"pubmed_title":["Comparative molecular analyses of left-sided colon, right-sided colon, and rectal cancers."],"pmcid":["PMC5689690"],"funding_grant_id":["U10 CA180830"],"pubmed_authors":["Weinberg BA","El-Deiry WS","Lenz HJ","Shields AF","Xiu J","Salem ME","Hwang JJ","Marshall JL","Gatalica Z","Philip PA"],"additional_accession":[]},"is_claimable":false,"name":"Comparative molecular analyses of left-sided colon, right-sided colon, and rectal cancers.","description":"Tumor sidedness has emerged as an important prognostic and predictive factor in the treatment of colorectal cancer. Recent studies demonstrate that patients with advanced right-sided colon cancers have a worse prognosis than those with left-sided colon or rectal cancers, and these patient subgroups respond differently to biological therapies. Historically, management of patients with metastatic colon and rectal cancers has been similar, and colon and rectal cancer patients have been grouped together in large clinical trials. Clearly, the differences in molecular biology among right-sided colon, left-sided colon, and rectal cancers should be further studied in order to account for disparities in clinical outcomes. We profiled 10,570 colorectal tumors (of which 2,413 were identified as arisi","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Oct","modification":"2025-04-22T07:35:47.543Z","creation":"2019-03-27T03:02:10Z"},"accession":"S-EPMC5689690","cross_references":{"pubmed":["29156800"],"doi":["10.18632/oncotarget.21169"]}}