{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Chen A"],"funding":["CIHR"],"pubmed_abstract":["Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the segregating chromosomal masses to divide a cell into two. Here we show that the stabilization and organization of the cytokinetic furrow is specifically dependent on localized β-actin filament assembly at the site of cytokinesis. β-actin filaments are assembled directly at the furrow by an anillin-dependent pathway that enhances RhoA-dependent activation of the formin DIAPH3, an actin nucleator. DIAPH3 specifically generates homopolymeric filaments of β-actin in vitro. By employing enhancers and activators, cells can achieve acute spatio-temporal control over isoform-specific actin arrays that are required for distinct cellular functions."],"journal":["Nature communications"],"pagination":["1530"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5691081"],"repository":["biostudies-literature"],"pubmed_title":["Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator."],"pmcid":["PMC5691081"],"pubmed_authors":["Chen A","Wilde A","Arora PD","McCulloch CA"],"additional_accession":[]},"is_claimable":false,"name":"Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator.","description":"Cytokinesis is initiated by the localized assembly of the contractile ring, a dynamic actomyosin structure that generates a membrane furrow between the segregating chromosomal masses to divide a cell into two. Here we show that the stabilization and organization of the cytokinetic furrow is specifically dependent on localized β-actin filament assembly at the site of cytokinesis. β-actin filaments are assembled directly at the furrow by an anillin-dependent pathway that enhances RhoA-dependent activation of the formin DIAPH3, an actin nucleator. DIAPH3 specifically generates homopolymeric filaments of β-actin in vitro. By employing enhancers and activators, cells can achieve acute spatio-temporal control over isoform-specific actin arrays that are required for distinct cellular functions.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Nov","modification":"2025-04-04T14:03:26.7Z","creation":"2019-03-27T03:02:16Z"},"accession":"S-EPMC5691081","cross_references":{"pubmed":["29146911"],"doi":["10.1038/s41467-017-01231-x"]}}