biostudies-literatureMcEvoy CTNational Center for Advancing Translational SciencesOffice of Dietary SupplementsNCATS NIH HHSOregon Clinical and Translational Research InstituteNHLBI NIH HHSNational Heart, Lung, and Blood InstituteNational Institutes of HealthNIH HHS66-77https://www.ebi.ac.uk/biostudies/studies/S-EPMC5696784biostudies-literatureUnknown58Despite strong anti-smoking efforts, at least 12% of American women cannot quit smoking when pregnant resulting in >450,000 smoke-exposed infants born yearly. Smoking during pregnancy is the largest preventable cause of childhood respiratory illness including wheezing and asthma. Recent studies have shown a protective effect of vitamin C supplementation on the lung function of offspring exposed to in utero smoke in a non-human primate model and an initial human trial. Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) is a randomized, double-blind, placebo-controlled trial to evaluate pulmonary function at 3months of age in infants delivered to pregnant smokers randomized to 500mg/day of vitamin C versus placebo during pregnancy. Secondary aims evaluaContemporary clinical trialsVitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco smoke exposure on infant lung function and respiratory health.PMC5696784R01 HL105460UL1TR000128UL1 TR000128UL1 TR002369P51 OD011092R01 HL105447Mitchell JPeters DMetz JTepper RSMcEvoy CTSchilling DGSpindel ERSchuff RHaas DVuylsteke BShorey-Kendrick LEScherman AJMorris CDMilner KFTiller CJJackson KfalseVitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP): Rationale, design, and methods of a randomized, controlled trial of vitamin C supplementation in pregnancy for the primary prevention of effects of in utero tobacco smoke exposure on infant lung function and respiratory health.Despite strong anti-smoking efforts, at least 12% of American women cannot quit smoking when pregnant resulting in >450,000 smoke-exposed infants born yearly. Smoking during pregnancy is the largest preventable cause of childhood respiratory illness including wheezing and asthma. Recent studies have shown a protective effect of vitamin C supplementation on the lung function of offspring exposed to in utero smoke in a non-human primate model and an initial human trial. Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) is a randomized, double-blind, placebo-controlled trial to evaluate pulmonary function at 3months of age in infants delivered to pregnant smokers randomized to 500mg/day of vitamin C versus placebo during pregnancy. Secondary aims evalua2017-01-01T00:00:00Z2017 Jul2025-04-04T14:10:00.156Z2019-03-26T23:44:08ZS-EPMC56967842849562010.1016/j.cct.2017.05.008