{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Devambez I"],"funding":["NIH HHS"],"pagination":["16254"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5701211"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(1)"],"pubmed_abstract":["Microtubules (MTs) play crucial roles during neuronal life. They are formed by heterodimers of alpha and beta-tubulins, which are subjected to several post-translational modifications (PTMs). Amongst them, glutamylation consists in the reversible addition of a variable number of glutamate residues to the C-terminal tails of tubulins. Glutamylation is the most abundant MT PTM in the mammalian adult brain, suggesting that it plays an important role in the nervous system (NS). Here, we show that the previously uncharacterized CG31108 gene encodes an alpha-tubulin glutamylase acting in the Drosophila NS. We show that this glutamylase, which we named DmTTLL5, initiates MT glutamylation specifically on alpha-tubulin, which are the only glutamylated tubulin in the Drosophila brain. In DmTTLL5 mut"],"journal":["Scientific reports"],"pubmed_title":["Identification of DmTTLL5 as a Major Tubulin Glutamylase in the Drosophila Nervous System."],"pmcid":["PMC5701211"],"funding_grant_id":["P40 OD018537"],"pubmed_authors":["Devambez I","Layalle S","Grau Y","Benlefki S","Parmentier ML","Soustelle L","Rogowski K","van Dijk J"],"additional_accession":[]},"is_claimable":false,"name":"Identification of DmTTLL5 as a Major Tubulin Glutamylase in the Drosophila Nervous System.","description":"Microtubules (MTs) play crucial roles during neuronal life. They are formed by heterodimers of alpha and beta-tubulins, which are subjected to several post-translational modifications (PTMs). Amongst them, glutamylation consists in the reversible addition of a variable number of glutamate residues to the C-terminal tails of tubulins. Glutamylation is the most abundant MT PTM in the mammalian adult brain, suggesting that it plays an important role in the nervous system (NS). Here, we show that the previously uncharacterized CG31108 gene encodes an alpha-tubulin glutamylase acting in the Drosophila NS. We show that this glutamylase, which we named DmTTLL5, initiates MT glutamylation specifically on alpha-tubulin, which are the only glutamylated tubulin in the Drosophila brain. In DmTTLL5 mut","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Nov","modification":"2025-05-31T23:56:55.121Z","creation":"2025-05-31T23:56:55.121Z"},"accession":"S-EPMC5701211","cross_references":{"pubmed":["29176602"],"doi":["10.1038/s41598-017-16586-w"]}}