{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Armartmuntree N"],"funding":["Khon Kaen University"],"pagination":["637-644"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5701798"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14"],"pubmed_abstract":["Early B cell factor 1 (EBF1) is a transcription factor involved in the differentiation of several stem cell lineages and it is a negative regulator of estrogen receptors. EBF1 is down-regulated in many tumors, and is believed to play suppressive roles in cancer promotion and progression. However, the functional roles of EBF1 in carcinogenesis are unclear. Liver fluke-infection-associated cholangiocarcinoma (CCA) is an oxidative stress-driven cancer of bile duct epithelium. In this study, we investigated EBF1 expression in tissues from CCA patients, CCA cell lines (KKU-213, KKU-214 and KKU-156), cholangiocyte (MMNK1) and its oxidative stress-resistant (ox-MMNK1-L) cell lines. The formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) was used as an oxidative stress marker. Our results r"],"journal":["Redox biology"],"pubmed_title":["Prolonged oxidative stress down-regulates Early B cell factor 1 with inhibition of its tumor suppressive function against cholangiocarcinoma genesis."],"pmcid":["PMC5701798"],"funding_grant_id":["IN58140","I57327","LFCRC 003/2556","RSA5980031","591001"],"pubmed_authors":["Yongvanit P","Pinlaor S","Pairojkul C","Loilome W","Murata M","Sakonsinsiri C","Thanan R","Techasen A","Namwat N","Armartmuntree N"],"additional_accession":[]},"is_claimable":false,"name":"Prolonged oxidative stress down-regulates Early B cell factor 1 with inhibition of its tumor suppressive function against cholangiocarcinoma genesis.","description":"Early B cell factor 1 (EBF1) is a transcription factor involved in the differentiation of several stem cell lineages and it is a negative regulator of estrogen receptors. EBF1 is down-regulated in many tumors, and is believed to play suppressive roles in cancer promotion and progression. However, the functional roles of EBF1 in carcinogenesis are unclear. Liver fluke-infection-associated cholangiocarcinoma (CCA) is an oxidative stress-driven cancer of bile duct epithelium. In this study, we investigated EBF1 expression in tissues from CCA patients, CCA cell lines (KKU-213, KKU-214 and KKU-156), cholangiocyte (MMNK1) and its oxidative stress-resistant (ox-MMNK1-L) cell lines. The formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) was used as an oxidative stress marker. Our results r","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Apr","modification":"2025-04-18T19:46:16.875Z","creation":"2019-03-27T03:02:56Z"},"accession":"S-EPMC5701798","cross_references":{"pubmed":["29169115"],"doi":["10.1016/j.redox.2017.11.011"]}}