{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sugii H"],"funding":["NIDCR NIH HHS","National Institute of Dental and Craniofacial Research, National Institute of Health"],"pagination":["4037-4045"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5702075"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(21)"],"pubmed_abstract":["Craniofacial development depends on cell-cell interactions, coordinated cellular movement and differentiation under the control of regulatory gene networks, which include the distal-less (Dlx) gene family. However, the functional significance of <i>Dlx5</i> in patterning the oropharyngeal region has remained unknown. Here, we show that loss of <i>Dlx5</i> leads to a shortened soft palate and an absence of the levator veli palatini, palatopharyngeus and palatoglossus muscles that are derived from the 4th pharyngeal arch (PA); however, the tensor veli palatini, derived from the 1st PA, is unaffected. Dlx5-positive cranial neural crest (CNC) cells are in direct contact with myoblasts derived from the pharyngeal mesoderm, and <i>Dlx5</i> disruption leads to altered proliferation and apoptosis "],"journal":["Development (Cambridge, England)"],"pubmed_title":["The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development."],"pmcid":["PMC5702075"],"funding_grant_id":["U01 DE024421","R90 DE022528","R37 DE012711"],"pubmed_authors":["Grimaldi A","Vu-Ho T","Maeda H","Li J","Jing J","Feng J","Sugii H","Guo Y","Parada C","Chai Y","Yuan Y"],"additional_accession":[]},"is_claimable":false,"name":"The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development.","description":"Craniofacial development depends on cell-cell interactions, coordinated cellular movement and differentiation under the control of regulatory gene networks, which include the distal-less (Dlx) gene family. However, the functional significance of <i>Dlx5</i> in patterning the oropharyngeal region has remained unknown. Here, we show that loss of <i>Dlx5</i> leads to a shortened soft palate and an absence of the levator veli palatini, palatopharyngeus and palatoglossus muscles that are derived from the 4th pharyngeal arch (PA); however, the tensor veli palatini, derived from the 1st PA, is unaffected. Dlx5-positive cranial neural crest (CNC) cells are in direct contact with myoblasts derived from the pharyngeal mesoderm, and <i>Dlx5</i> disruption leads to altered proliferation and apoptosis ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Nov","modification":"2026-04-16T17:21:27.74Z","creation":"2019-03-27T00:04:53Z"},"accession":"S-EPMC5702075","cross_references":{"pubmed":["28982687"],"doi":["10.1242/dev.155176"]}}