{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pacheco Y"],"funding":["Colciencias"],"pagination":["239"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5702157"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine. Therefore, the relationship between autoantibody and cytokine clusters in SLE was analyzed.<h4>Methods</h4>This was an exploratory study in which 67 consecutive women with established SLE were assessed. Clinical characteristics including disease activity, a 14-autoantibody profile,"],"journal":["Journal of translational medicine"],"pubmed_title":["Cytokine and autoantibody clusters interaction in systemic lupus erythematosus."],"pmcid":["PMC5702157"],"funding_grant_id":["0425-2013","122254531722"],"pubmed_authors":["Rojas M","Ramirez-Santana C","Anaya JM","Rodriguez-Jimenez M","Molano-Gonzalez N","Saavedra J","Mantilla RD","Barahona-Correa J","Acosta-Ampudia Y","Rodriguez Y","Pacheco Y","Monsalve DM"],"additional_accession":[]},"is_claimable":false,"name":"Cytokine and autoantibody clusters interaction in systemic lupus erythematosus.","description":"<h4>Background</h4>Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and the pivotal role of cytokines and autoantibodies, which interact in a highly complex network. Thus, understanding how these complex nonlinear processes are connected and observed in real-life settings is a major challenge. Cluster approaches may assist in the identification of these subphenotypes, which represent such a phenomenon, and may contribute to the development of personalized medicine. Therefore, the relationship between autoantibody and cytokine clusters in SLE was analyzed.<h4>Methods</h4>This was an exploratory study in which 67 consecutive women with established SLE were assessed. Clinical characteristics including disease activity, a 14-autoantibody profile,","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Nov","modification":"2025-04-18T19:47:49.551Z","creation":"2019-03-27T03:02:57Z"},"accession":"S-EPMC5702157","cross_references":{"pubmed":["29178890"],"doi":["10.1186/s12967-017-1345-y"]}}