biostudies-literatureBerg ATNINDS NIH HHS863-871https://www.ebi.ac.uk/biostudies/studies/S-EPMC5710404biostudies-literatureUnknown171(9)<h4>Importance</h4>Early-life epilepsies are often a consequence of numerous neurodevelopmental disorders, most of which are proving to have genetic origins. The role of genetic testing in the initial evaluation of these epilepsies is not established.<h4>Objective</h4>To provide a contemporary account of the patterns of use and diagnostic yield of genetic testing for early-life epilepsies.<h4>Design, setting, and participants</h4>In this prospective cohort, children with newly diagnosed epilepsy with an onset at less than 3 years of age were recruited from March 1, 2012, to April 30, 2015, from 17 US pediatric hospitals and followed up for 1 year. Of 795 families approached, 775 agreed to participate. Clinical diagnosis of the etiology of epilepsy were characterized based on information avJAMA pediatricsEarly-Life Epilepsies and the Emerging Role of Genetic Testing.PMC5710404K23 NS092923R21 NS094999R01 NS092772R01 NS073768K12 NS066274Saneto RPKnupp KGKossoff EHNovotny EJKoh SGaillard WDShellhaas RARyan NKekis MDobyns WBGrinspan ZMBerg ATAlexander JJCoryell JMytinger JRWusthoff CChu CJSullivan JEKeator CLoddenkemper TWirrell ECValencia IfalseEarly-Life Epilepsies and the Emerging Role of Genetic Testing.<h4>Importance</h4>Early-life epilepsies are often a consequence of numerous neurodevelopmental disorders, most of which are proving to have genetic origins. The role of genetic testing in the initial evaluation of these epilepsies is not established.<h4>Objective</h4>To provide a contemporary account of the patterns of use and diagnostic yield of genetic testing for early-life epilepsies.<h4>Design, setting, and participants</h4>In this prospective cohort, children with newly diagnosed epilepsy with an onset at less than 3 years of age were recruited from March 1, 2012, to April 30, 2015, from 17 US pediatric hospitals and followed up for 1 year. Of 795 families approached, 775 agreed to participate. Clinical diagnosis of the etiology of epilepsy were characterized based on information av2017-01-01T00:00:00Z2017 Sep2026-05-02T18:45:14.594Z2019-03-26T23:54:22ZS-EPMC57104042875966710.1001/jamapediatrics.2017.1743