biostudies-literatureSchultz KAPThe Parson&apos;s FoundationNCI NIH HHSNational Institutes of Health521-527https://www.ebi.ac.uk/biostudies/studies/S-EPMC5716477biostudies-literatureUnknown147(3)<h4>Background</h4>Ovarian sex cord-stromal tumors (OSCST) include juvenile granulosa cell tumors (JGCT), Sertoli-Leydig cell tumor (SLCT) and gynandroblastoma (GAB) among others. These ovarian sex cord-stromal tumors as well as other tumors including pleuropulmonary blastoma (PPB) may be associated with DICER1 mutations. We sought to describe the clinical and genetic findings from the first 107 individuals enrolled in the International Ovarian and Testicular Stromal Tumor Registry.<h4>Methods</h4>Medical and family history were obtained for individuals consecutively enrolled in the International Ovarian and Testicular Stromal Tumor Registry. Pathology was centrally reviewed. DICER1 sequencing was performed on blood and tumor tissue.<h4>Results</h4>Of the 107 participants, 49 had SLCT, 25 Gynecologic oncologyDICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry.PMC5716477R01 CA143167NCI R01CA143167L40 CA171135Finch MSchneider DTHill DAStewart DRSchultz KAPFrazier ALDehner LPTurner JGershenson DMMessinger YField AYu WCost NGHarris AKYoung RHBrown JBfalseDICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry.<h4>Background</h4>Ovarian sex cord-stromal tumors (OSCST) include juvenile granulosa cell tumors (JGCT), Sertoli-Leydig cell tumor (SLCT) and gynandroblastoma (GAB) among others. These ovarian sex cord-stromal tumors as well as other tumors including pleuropulmonary blastoma (PPB) may be associated with DICER1 mutations. We sought to describe the clinical and genetic findings from the first 107 individuals enrolled in the International Ovarian and Testicular Stromal Tumor Registry.<h4>Methods</h4>Medical and family history were obtained for individuals consecutively enrolled in the International Ovarian and Testicular Stromal Tumor Registry. Pathology was centrally reviewed. DICER1 sequencing was performed on blood and tumor tissue.<h4>Results</h4>Of the 107 participants, 49 had SLCT, 25 2017-01-01T00:00:00Z2017 Dec2026-05-05T20:56:09.464Z2019-03-27T00:09:19ZS-EPMC57164772903780710.1016/j.ygyno.2017.09.034