{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chiasson DM"],"funding":["Deutsche Forschungsgemeinschaft","European Research Council","Alexander von Humboldt-Stiftung"],"pagination":["e25012"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5716663"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["The coordinated control of Ca<sup>2+</sup> signaling is essential for development in eukaryotes. Cyclic nucleotide-gated channel (CNGC) family members mediate Ca<sup>2+</sup> influx from cellular stores in plants (Charpentier et al., 2016; Gao et al., 2016; Frietsch et al., 2007; Urquhart et al., 2007). Here, we report the unusual genetic behavior of a quantitative gain-of-function <i>CNGC</i> mutation (<i>brush</i>) in <i>Lotus japonicus</i> resulting in a leaky tetrameric channel. <i>brush</i> resides in a cluster of redundant <i>CNGCs</i> encoding subunits which resemble metazoan voltage-gated potassium (Kv1-Kv4) channels in assembly and gating properties. The recessive mongenic <i>brush</i> mutation impaired root development and infection by nitrogen-fixing rhizobia. The <i>brush</i> a"],"journal":["eLife"],"pubmed_title":["A quantitative hypermorphic <i>CNGC</i> allele confers ectopic calcium flux and impairs cellular development."],"pmcid":["PMC5716663"],"funding_grant_id":["340904 (EvolvingNodules)","FOR964 (Calcium)","340904"],"pubmed_authors":["Chiasson DM","Brachmann A","Parniske M","Sollweck K","Dietrich P","Haage K"],"additional_accession":[]},"is_claimable":false,"name":"A quantitative hypermorphic <i>CNGC</i> allele confers ectopic calcium flux and impairs cellular development.","description":"The coordinated control of Ca<sup>2+</sup> signaling is essential for development in eukaryotes. Cyclic nucleotide-gated channel (CNGC) family members mediate Ca<sup>2+</sup> influx from cellular stores in plants (Charpentier et al., 2016; Gao et al., 2016; Frietsch et al., 2007; Urquhart et al., 2007). Here, we report the unusual genetic behavior of a quantitative gain-of-function <i>CNGC</i> mutation (<i>brush</i>) in <i>Lotus japonicus</i> resulting in a leaky tetrameric channel. <i>brush</i> resides in a cluster of redundant <i>CNGCs</i> encoding subunits which resemble metazoan voltage-gated potassium (Kv1-Kv4) channels in assembly and gating properties. The recessive mongenic <i>brush</i> mutation impaired root development and infection by nitrogen-fixing rhizobia. The <i>brush</i> a","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Sep","modification":"2026-05-05T21:11:56.979Z","creation":"2019-03-27T03:03:57Z"},"accession":"S-EPMC5716663","cross_references":{"pubmed":["28933692"],"doi":["10.7554/eLife.25012"]}}