{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":48,"searchCount":0},"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Leijenaar JF"],"pubmed_abstract":["Introduction:In this cross-sectional study, we aimed to detect differences in cerebral blood flow (CBF) between subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD), using two-dimensional phase-contrast magnetic resonance imaging. Methods:We included 74 AD patients (67 years, 51% female), 36 MCI patients (66 years, 33% female), and 62 patients with SCD (60 years, 32% female) from the Amsterdam Dementia Cohort. Patients with SCD are those who visited the memory clinic with subjective cognitive complaints without objective cognitive impairment. Whole-brain CBF (mL/100 g/min) was calculated using total volume flow measured with two-dimensional phase-contrast magnetic resonance imaging and normalized for brain volume. Results:Mean CBF values (SD) were lower in AD compared to SCD (age and sex adjusted 70 ± 26 vs. 82 ± 24 mL/100 g/min, P < .05). Mean CBF values of MCI were comparable to AD. Across clinical groups, lower CBF was associated with lower scores on the Mini-Mental State Examination (age and sex adjusted st? = 0.19 per mL/100 g/min; P = .02). Discussion:Lower whole-brain CBF is seen in AD patients compared to SCD patients and is associated with worse cognitive function."],"journal":["Alzheimer's & dementia (Amsterdam, Netherlands)"],"pagination":["76-83"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5717294"],"repository":["biostudies-literature"],"pubmed_title":["Lower cerebral blood flow in subjects with Alzheimer's dementia, mild cognitive impairment, and subjective cognitive decline using two-dimensional phase-contrast magnetic resonance imaging."],"pmcid":["PMC5717294"],"pubmed_authors":["van der Flier WM","van Maurik IS","Scheltens P","Kuijer JPA","Barkhof F","Prins ND","Leijenaar JF"],"view_count":["48"],"additional_accession":[]},"is_claimable":false,"name":"Lower cerebral blood flow in subjects with Alzheimer's dementia, mild cognitive impairment, and subjective cognitive decline using two-dimensional phase-contrast magnetic resonance imaging.","description":"Introduction:In this cross-sectional study, we aimed to detect differences in cerebral blood flow (CBF) between subjects with Alzheimer's disease (AD), mild cognitive impairment (MCI), and subjective cognitive decline (SCD), using two-dimensional phase-contrast magnetic resonance imaging. Methods:We included 74 AD patients (67 years, 51% female), 36 MCI patients (66 years, 33% female), and 62 patients with SCD (60 years, 32% female) from the Amsterdam Dementia Cohort. Patients with SCD are those who visited the memory clinic with subjective cognitive complaints without objective cognitive impairment. Whole-brain CBF (mL/100 g/min) was calculated using total volume flow measured with two-dimensional phase-contrast magnetic resonance imaging and normalized for brain volume. Results:Mean CBF values (SD) were lower in AD compared to SCD (age and sex adjusted 70 ± 26 vs. 82 ± 24 mL/100 g/min, P < .05). Mean CBF values of MCI were comparable to AD. Across clinical groups, lower CBF was associated with lower scores on the Mini-Mental State Examination (age and sex adjusted st? = 0.19 per mL/100 g/min; P = .02). Discussion:Lower whole-brain CBF is seen in AD patients compared to SCD patients and is associated with worse cognitive function.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2021-02-20T23:29:22Z","creation":"2019-03-27T03:04:00Z"},"accession":"S-EPMC5717294","cross_references":{"pubmed":["29234724"],"doi":["10.1016/j.dadm.2017.10.001"]}}