{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(8)"],"submitter":["Gastelurrutia P"],"funding":["Ministerio de educación y ciencia","CIBERCV","Ministerio de Economía y Competitividad","PERIS Programme, Departament de Salut, Generalitat de Catalunya"],"pubmed_abstract":["

Introduction

Cardiac adipose tissue is a source of progenitor cells with regenerative capacity. Studies in rodents demonstrated that the intramyocardial delivery of cells derived from this tissue improves cardiac function after myocardial infarction (MI). We developed a new reparative approach for damaged myocardium that integrates the regenerative properties of cardiac adipose tissue with tissue engineering. In the adipose graft transposition procedure (AGTP), we dissect a vascularised flap of autologous pericardial adipose tissue and position it over the myocardial scarred area. Following encouraging results in acute and chronic MI porcine models, we performed the clinical trial (NCT01473433, AdiFLAP trial) to evaluate safety in patients with chronic MI undergoing coronary artery"],"journal":["BMJ open"],"pagination":["e017187"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5724153"],"repository":["biostudies-literature"],"pubmed_title":["Rationale and design of a multicentre, prospective, randomised, controlled clinical trial to evaluate the efficacy of the adipose graft transposition procedure in patients with a myocardial scar: the AGTP II trial."],"pmcid":["PMC5724153"],"pubmed_authors":["Caballero A","Garcia-Pavia P","Teis A","Nunez J","Gonzalez-Pinto A","Gastelurrutia P","Avanzas P","Cuenca-Castillo JJ","Alberto San Roman J","Brugada R","Camara ML","Melero JM","Crespo-Leiro MG","Martin C","Canovas SJ","Lupon J","Revilla-Orodea A","Silva J","Teresa E","Manito N","Fernandez-Aviles F","Pascual-Figal D","Galvez-Monton C","Bayes-Genis A","Bustamante-Munguira J"],"additional_accession":[]},"is_claimable":false,"name":"Rationale and design of a multicentre, prospective, randomised, controlled clinical trial to evaluate the efficacy of the adipose graft transposition procedure in patients with a myocardial scar: the AGTP II trial.","description":"

Introduction

Cardiac adipose tissue is a source of progenitor cells with regenerative capacity. Studies in rodents demonstrated that the intramyocardial delivery of cells derived from this tissue improves cardiac function after myocardial infarction (MI). We developed a new reparative approach for damaged myocardium that integrates the regenerative properties of cardiac adipose tissue with tissue engineering. In the adipose graft transposition procedure (AGTP), we dissect a vascularised flap of autologous pericardial adipose tissue and position it over the myocardial scarred area. Following encouraging results in acute and chronic MI porcine models, we performed the clinical trial (NCT01473433, AdiFLAP trial) to evaluate safety in patients with chronic MI undergoing coronary artery","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2026-05-03T03:52:57.577Z","creation":"2019-03-26T22:49:59Z"},"accession":"S-EPMC5724153","cross_references":{"pubmed":["28780562"],"doi":["10.1136/bmjopen-2017-017187"]}}