biostudies-literatureUnknown15(8)Cruz-Monteagudo M<h4>Background</h4>In the context of the current drug discovery efforts to find disease modifying therapies for Parkinson's disease (PD) the current single target strategy has proved inefficient. Consequently, the search for multi-potent agents is attracting more and more attention due to the multiple pathogenetic factors implicated in PD. Multiple evidences points to the dual inhibition of the monoamine oxidase B (MAO-B), as well as adenosine A2A receptor (A2AAR) blockade, as a promising approach to prevent the neurodegeneration involved in PD. Currently, only two chemical scaffolds has been proposed as potential dual MAO-B inhibitors/A2AAR antagonists (caffeine derivatives and benzothiazinones).<h4>Methods</h4>In this study, we conduct a series of chemoinformatics analysis in order to evCurrent neuropharmacology1117-1135https://www.ebi.ac.uk/biostudies/studies/S-EPMC5725544biostudies-literatureChemoinformatics Profiling of the Chromone Nucleus as a MAO-B/A2AAR Dual Binding Scaffold.PMC5725544Perera-Sardina YBorges FPerez-Castillo YCruz-Monteagudo MSanchez-Rodriguez ACordeiro MNDSHelguera AMPaz-Y-Mino CTejera EfalseChemoinformatics Profiling of the Chromone Nucleus as a MAO-B/A2AAR Dual Binding Scaffold.<h4>Background</h4>In the context of the current drug discovery efforts to find disease modifying therapies for Parkinson's disease (PD) the current single target strategy has proved inefficient. Consequently, the search for multi-potent agents is attracting more and more attention due to the multiple pathogenetic factors implicated in PD. Multiple evidences points to the dual inhibition of the monoamine oxidase B (MAO-B), as well as adenosine A2A receptor (A2AAR) blockade, as a promising approach to prevent the neurodegeneration involved in PD. Currently, only two chemical scaffolds has been proposed as potential dual MAO-B inhibitors/A2AAR antagonists (caffeine derivatives and benzothiazinones).<h4>Methods</h4>In this study, we conduct a series of chemoinformatics analysis in order to ev2017-01-01T00:00:00Z2017 Nov2026-04-16T05:10:48.884Z2019-03-26T23:35:56ZS-EPMC57255442809397610.2174/1570159X15666170116145316