{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["96(49)"],"submitter":["Wen Y"],"pubmed_abstract":["Introduction
Chemotherapy regimens are often a 2-drug regimen in concurrent chemotherapy and radiotherapy for esophageal cancer (EC). However, some retrospective studies have suggested that for patients with EC receiving radiotherapy combined with 2-drug chemotherapy have the severe toxicity. And S-1 alone with the combination of radiotherapy treatment effect is good, and achieved good clinical remission rate. The purpose of this trial is compare the efficacy and toxicity of combining S-1 or S-1 plus cisplatin with radiotherapy for esophageal squamous cell carcinoma.Methods/design
The study is a randomized, controlled, multicenter trial, comparing S-1 versus S-1 plus cisplatin concurrent radiotherapy for patients with esophageal squamous cell carcinoma. Eighty-eight patient"],"journal":["Medicine"],"pagination":["e8998"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5728890"],"repository":["biostudies-literature"],"pubmed_title":["S-1 versus S-1 plus cisplatin concurrent intensity modulated radiation therapy in the treatment of esophageal squamous cell carcinoma: Study protocol for a randomized controlled phase II trial."],"pmcid":["PMC5728890"],"pubmed_authors":["Wen Y","Jia Q","Sun M","Tian H","Du X","Liao D","Yang Q","Gui Y","Zhao Z","Yang C","Miao J"],"additional_accession":[]},"is_claimable":false,"name":"S-1 versus S-1 plus cisplatin concurrent intensity modulated radiation therapy in the treatment of esophageal squamous cell carcinoma: Study protocol for a randomized controlled phase II trial.","description":"Introduction
Chemotherapy regimens are often a 2-drug regimen in concurrent chemotherapy and radiotherapy for esophageal cancer (EC). However, some retrospective studies have suggested that for patients with EC receiving radiotherapy combined with 2-drug chemotherapy have the severe toxicity. And S-1 alone with the combination of radiotherapy treatment effect is good, and achieved good clinical remission rate. The purpose of this trial is compare the efficacy and toxicity of combining S-1 or S-1 plus cisplatin with radiotherapy for esophageal squamous cell carcinoma.Methods/design
The study is a randomized, controlled, multicenter trial, comparing S-1 versus S-1 plus cisplatin concurrent radiotherapy for patients with esophageal squamous cell carcinoma. Eighty-eight patient","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2025-04-04T14:40:01.918Z","creation":"2019-03-27T03:04:44Z"},"accession":"S-EPMC5728890","cross_references":{"pubmed":["29245275"],"doi":["10.1097/MD.0000000000008998","10.1097/md.0000000000008998"]}}