{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Coveleskie K"],"funding":["National Institute of Health (National Institute of Diabetes and Digestive and Kidney Disease)","NIDDK NIH HHS","Ahmanson-Lovelace Brain Mapping Center"],"pagination":["434-445"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5729499"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(4)"],"pubmed_abstract":["Objective
The differential effect of GLP-1 agonist Exenatide on functional connectivity of the nucleus tractus solitaries (NTS), a key region associated with homeostasis, and on appetite-related behaviours was investigated in women with normal weight compared with women with obesity.Methods
Following an 8-h fast, 19 female subjects (11 lean, 8 obese) participated in a 2-d double blind crossover study. Subjects underwent functional magnetic resonance imaging at fast and 30-min post subcutaneous injection of 5 μg of Exenatide or placebo. Functional connectivity was examined with the NTS. Drug-induced functional connectivity changes within and between groups and correlations with appetite measures were examined in a region of interest approach focusing on the thalamus and hypo"],"journal":["Obesity science & practice"],"pubmed_title":["The effect of the GLP-1 analogue Exenatide on functional connectivity within an NTS-based network in women with and without obesity."],"pmcid":["PMC5729499"],"funding_grant_id":["P50 DK064539","P30 DK041301","R01 DK048351","K23 DK106528","K01 DK085133"],"pubmed_authors":["Connolly L","Gupta A","Sanmiguel C","Labus JS","Coveleskie K","Kilpatrick LA","Stains J","Mayer EA"],"additional_accession":[]},"is_claimable":false,"name":"The effect of the GLP-1 analogue Exenatide on functional connectivity within an NTS-based network in women with and without obesity.","description":"Objective
The differential effect of GLP-1 agonist Exenatide on functional connectivity of the nucleus tractus solitaries (NTS), a key region associated with homeostasis, and on appetite-related behaviours was investigated in women with normal weight compared with women with obesity.Methods
Following an 8-h fast, 19 female subjects (11 lean, 8 obese) participated in a 2-d double blind crossover study. Subjects underwent functional magnetic resonance imaging at fast and 30-min post subcutaneous injection of 5 μg of Exenatide or placebo. Functional connectivity was examined with the NTS. Drug-induced functional connectivity changes within and between groups and correlations with appetite measures were examined in a region of interest approach focusing on the thalamus and hypo","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2025-04-26T00:54:01.116Z","creation":"2019-03-27T03:04:46Z"},"accession":"S-EPMC5729499","cross_references":{"pubmed":["29259802"],"doi":["10.1002/osp4.124"]}}