biostudies-literatureCoveleskie KNational Institute of Health (National Institute of Diabetes and Digestive and Kidney Disease)NIDDK NIH HHSAhmanson-Lovelace Brain Mapping Center434-445https://www.ebi.ac.uk/biostudies/studies/S-EPMC5729499biostudies-literatureUnknown3(4)<h4>Objective</h4>The differential effect of GLP-1 agonist Exenatide on functional connectivity of the nucleus tractus solitaries (NTS), a key region associated with homeostasis, and on appetite-related behaviours was investigated in women with normal weight compared with women with obesity.<h4>Methods</h4>Following an 8-h fast, 19 female subjects (11 lean, 8 obese) participated in a 2-d double blind crossover study. Subjects underwent functional magnetic resonance imaging at fast and 30-min post subcutaneous injection of 5 μg of Exenatide or placebo. Functional connectivity was examined with the NTS. Drug-induced functional connectivity changes within and between groups and correlations with appetite measures were examined in a region of interest approach focusing on the thalamus and hypoObesity science & practiceThe effect of the GLP-1 analogue Exenatide on functional connectivity within an NTS-based network in women with and without obesity.PMC5729499P50 DK064539P30 DK041301R01 DK048351K23 DK106528K01 DK085133Connolly LGupta ASanmiguel CLabus JSCoveleskie KKilpatrick LAStains JMayer EAfalseThe effect of the GLP-1 analogue Exenatide on functional connectivity within an NTS-based network in women with and without obesity.<h4>Objective</h4>The differential effect of GLP-1 agonist Exenatide on functional connectivity of the nucleus tractus solitaries (NTS), a key region associated with homeostasis, and on appetite-related behaviours was investigated in women with normal weight compared with women with obesity.<h4>Methods</h4>Following an 8-h fast, 19 female subjects (11 lean, 8 obese) participated in a 2-d double blind crossover study. Subjects underwent functional magnetic resonance imaging at fast and 30-min post subcutaneous injection of 5 μg of Exenatide or placebo. Functional connectivity was examined with the NTS. Drug-induced functional connectivity changes within and between groups and correlations with appetite measures were examined in a region of interest approach focusing on the thalamus and hypo2017-01-01T00:00:00Z2017 Dec2025-04-26T00:54:01.116Z2019-03-27T03:04:46ZS-EPMC57294992925980210.1002/osp4.124