{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim MH"],"funding":["Korean Health Technology R&amp;D Project, Ministry of Health &amp; Welfare, Republic of Korea"],"pagination":["e0190068"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5739476"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(12)"],"pubmed_abstract":["<h4>Objective</h4>Bkv-miR-B1-5p, one of the microRNAs encoded by BK virus, was recently reported to be elevated in the blood among the patients with BK virus nephropathy (BKVN). Urinary exosome was suggested to be a possible source of biomarker for kidney diseases, but it was unknown whether it could contain viral microRNA as well as human microRNAs. The aim of this study was to evaluate whether urinary exosomal BK viral microRNA were expressed during replication and could be used to diagnose BKVN in kidney transplant recipients.<h4>Materials and methods</h4>In a cross-sectional multicenter study, we collected and analyzed 458 graft biopsies from 385 kidney transplant recipients. Urine samples were collected at the time of graft biopsy, and microRNAs in urinary exosome were measured once. "],"journal":["PloS one"],"pubmed_title":["Urinary exosomal viral microRNA as a marker of BK virus nephropathy in kidney transplant recipients."],"pmcid":["PMC5739476"],"funding_grant_id":["HI13C1232"],"pubmed_authors":["Jeong KH","Chung BH","Kim CD","Lee SH","Kim YG","Ihm CG","Lee YH","Kim JS","Seo JW","Kim YH","Moon JY","Kim MH","Lee TW","Moon H","Park JB"],"additional_accession":[]},"is_claimable":false,"name":"Urinary exosomal viral microRNA as a marker of BK virus nephropathy in kidney transplant recipients.","description":"<h4>Objective</h4>Bkv-miR-B1-5p, one of the microRNAs encoded by BK virus, was recently reported to be elevated in the blood among the patients with BK virus nephropathy (BKVN). Urinary exosome was suggested to be a possible source of biomarker for kidney diseases, but it was unknown whether it could contain viral microRNA as well as human microRNAs. The aim of this study was to evaluate whether urinary exosomal BK viral microRNA were expressed during replication and could be used to diagnose BKVN in kidney transplant recipients.<h4>Materials and methods</h4>In a cross-sectional multicenter study, we collected and analyzed 458 graft biopsies from 385 kidney transplant recipients. Urine samples were collected at the time of graft biopsy, and microRNAs in urinary exosome were measured once. ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-04-05T12:33:01.591Z","creation":"2019-03-27T03:05:29Z"},"accession":"S-EPMC5739476","cross_references":{"pubmed":["29267352"],"doi":["10.1371/journal.pone.0190068"]}}