{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Parsons SDC"],"funding":["South African Medical Research Council","National Research Foundation"],"pagination":["1831"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5743672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["<i>Mycobacterium bovis</i> is the cause of tuberculosis (TB) in a wide range of species, including white rhinoceroses (<i>Ceratotherium simum</i>). Control of the disease relies on the indirect detection of infection by measuring pathogen-specific responses of the host. These are poorly described in the white rhinoceros and this study aimed to characterize the kinetics of immune responses to <i>M. bovis</i> infection in this species. Three white rhinoceroses were infected with <i>M. bovis</i> and their immune sensitization to this pathogen was measured monthly for 20 months. Cell-mediated immunity was characterized in whole blood samples as the differential release of interferon-gamma in response to bovine purified protein derivative (PPDb) and avian PPD (PPDa) as well as the release of th"],"journal":["Frontiers in immunology"],"pubmed_title":["The Kinetics of the Humoral and Interferon-Gamma Immune Responses to Experimental <i>Mycobacterium bovis</i> Infection in the White Rhinoceros (<i>Ceratotherium simum</i>)."],"pmcid":["PMC5743672"],"funding_grant_id":["41744, 86949, Incentive Funding for Rated Researchers"],"pubmed_authors":["Morar-Leather D","Michel AL","Buss P","McFadyen R","Rutten VPMG","Miller MA","Parsons SDC","van Helden PD","Hofmeyr J"],"additional_accession":[]},"is_claimable":false,"name":"The Kinetics of the Humoral and Interferon-Gamma Immune Responses to Experimental <i>Mycobacterium bovis</i> Infection in the White Rhinoceros (<i>Ceratotherium simum</i>).","description":"<i>Mycobacterium bovis</i> is the cause of tuberculosis (TB) in a wide range of species, including white rhinoceroses (<i>Ceratotherium simum</i>). Control of the disease relies on the indirect detection of infection by measuring pathogen-specific responses of the host. These are poorly described in the white rhinoceros and this study aimed to characterize the kinetics of immune responses to <i>M. bovis</i> infection in this species. Three white rhinoceroses were infected with <i>M. bovis</i> and their immune sensitization to this pathogen was measured monthly for 20 months. Cell-mediated immunity was characterized in whole blood samples as the differential release of interferon-gamma in response to bovine purified protein derivative (PPDb) and avian PPD (PPDa) as well as the release of th","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017","modification":"2025-05-29T16:10:36.108Z","creation":"2025-05-29T16:10:36.108Z"},"accession":"S-EPMC5743672","cross_references":{"pubmed":["29312328"],"doi":["10.3389/fimmu.2017.01831"]}}