biostudies-literatureParsons SDCSouth African Medical Research CouncilNational Research Foundation1831https://www.ebi.ac.uk/biostudies/studies/S-EPMC5743672biostudies-literatureUnknown8<i>Mycobacterium bovis</i> is the cause of tuberculosis (TB) in a wide range of species, including white rhinoceroses (<i>Ceratotherium simum</i>). Control of the disease relies on the indirect detection of infection by measuring pathogen-specific responses of the host. These are poorly described in the white rhinoceros and this study aimed to characterize the kinetics of immune responses to <i>M. bovis</i> infection in this species. Three white rhinoceroses were infected with <i>M. bovis</i> and their immune sensitization to this pathogen was measured monthly for 20 months. Cell-mediated immunity was characterized in whole blood samples as the differential release of interferon-gamma in response to bovine purified protein derivative (PPDb) and avian PPD (PPDa) as well as the release of thFrontiers in immunologyThe Kinetics of the Humoral and Interferon-Gamma Immune Responses to Experimental <i>Mycobacterium bovis</i> Infection in the White Rhinoceros (<i>Ceratotherium simum</i>).PMC574367241744, 86949, Incentive Funding for Rated ResearchersMorar-Leather DMichel ALBuss PMcFadyen RRutten VPMGMiller MAParsons SDCvan Helden PDHofmeyr JfalseThe Kinetics of the Humoral and Interferon-Gamma Immune Responses to Experimental <i>Mycobacterium bovis</i> Infection in the White Rhinoceros (<i>Ceratotherium simum</i>).<i>Mycobacterium bovis</i> is the cause of tuberculosis (TB) in a wide range of species, including white rhinoceroses (<i>Ceratotherium simum</i>). Control of the disease relies on the indirect detection of infection by measuring pathogen-specific responses of the host. These are poorly described in the white rhinoceros and this study aimed to characterize the kinetics of immune responses to <i>M. bovis</i> infection in this species. Three white rhinoceroses were infected with <i>M. bovis</i> and their immune sensitization to this pathogen was measured monthly for 20 months. Cell-mediated immunity was characterized in whole blood samples as the differential release of interferon-gamma in response to bovine purified protein derivative (PPDb) and avian PPD (PPDa) as well as the release of th2017-01-01T00:00:00Z20172025-05-29T16:10:36.108Z2025-05-29T16:10:36.108ZS-EPMC57436722931232810.3389/fimmu.2017.01831