{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Campbell NG"],"funding":["British Heart Foundation"],"pagination":["618"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5745783"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<h4>Background</h4>Atrial fibrillation (AF) occurs in approximately one in three patients after cardiac surgery, and is associated with increased short-term and long-term mortality, intensive care unit (ICU) and hospital stay, and increased cost of care. In an attempt to reduce AF incidence in these patients, serum potassium (K+) levels are commonly maintained at the high end of normal (4.5-5.5 mEq/L). However, such potassium supplementation is without proven benefit, and is not without negative consequences. It carries clinical risk, negatively impacts patient experience and is both time-consuming and costly. This protocol describes a randomised controlled pilot trial to assess the feasibility of a proposed randomised non-inferiority trial to investigate the impact of maintaining serum po"],"journal":["Trials"],"pubmed_title":["The impact of maintaining serum potassium ≥3.6 mEq/L vs ≥4.5 mEq/L on the incidence of new-onset atrial fibrillation in the first 120 hours after isolated elective coronary artery bypass grafting - study protocol for a randomised feasibility trial for the proposed Tight K randomized non-inferiority trial."],"pmcid":["PMC5745783"],"funding_grant_id":["PG/16/15/32050"],"pubmed_authors":["Campbell NG","Sanders J","O'Brien B","Swinson R","Sturgess J","Montgomery H","Allen E","Birch S","Elbourne D","Al-Subaie N"],"additional_accession":[]},"is_claimable":false,"name":"The impact of maintaining serum potassium ≥3.6 mEq/L vs ≥4.5 mEq/L on the incidence of new-onset atrial fibrillation in the first 120 hours after isolated elective coronary artery bypass grafting - study protocol for a randomised feasibility trial for the proposed Tight K randomized non-inferiority trial.","description":"<h4>Background</h4>Atrial fibrillation (AF) occurs in approximately one in three patients after cardiac surgery, and is associated with increased short-term and long-term mortality, intensive care unit (ICU) and hospital stay, and increased cost of care. In an attempt to reduce AF incidence in these patients, serum potassium (K+) levels are commonly maintained at the high end of normal (4.5-5.5 mEq/L). However, such potassium supplementation is without proven benefit, and is not without negative consequences. It carries clinical risk, negatively impacts patient experience and is both time-consuming and costly. This protocol describes a randomised controlled pilot trial to assess the feasibility of a proposed randomised non-inferiority trial to investigate the impact of maintaining serum po","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2026-06-09T06:39:41.107Z","creation":"2019-03-27T03:05:53Z"},"accession":"S-EPMC5745783","cross_references":{"pubmed":["29282098"],"doi":["10.1186/s13063-017-2349-x"]}}