{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(64)"],"submitter":["Wang P"],"pubmed_abstract":["Stroke is one of the most common causes of death worldwide. Genetic risk factors have been found to play important roles in the pathology of ischemic stroke. In a previous genome-wide association study, a functional variant (rs9943582, -154G/A) in the 5' flanking region of the apelin receptor gene (<i>APLNR</i>) was shown to be significantly associated with stroke in the Japanese population. However, the association required validation in other ethnicities. To validate the genetic relationship between <i>APLNR</i> and ischemic stroke in the Chinese Han population, we genotyped rs9943582 in a case-control population containing 1,158 ischemic stroke patients and 1,265 common controls enrolled from the GeneID database, and performed a genetic association study. We detected no allelic or genot"],"journal":["Oncotarget"],"pagination":["107678-107684"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC5746099"],"repository":["biostudies-literature"],"pubmed_title":["Lack of association between the <i>APLNR</i> variant rs9943582 with ischemic stroke in the Chinese Han GeneID population."],"pmcid":["PMC5746099"],"pubmed_authors":["Wang P","Xiong L","Li S","Wang B","Wang C","Wang QK","Xu CQ","Tu X"],"additional_accession":[]},"is_claimable":false,"name":"Lack of association between the <i>APLNR</i> variant rs9943582 with ischemic stroke in the Chinese Han GeneID population.","description":"Stroke is one of the most common causes of death worldwide. Genetic risk factors have been found to play important roles in the pathology of ischemic stroke. In a previous genome-wide association study, a functional variant (rs9943582, -154G/A) in the 5' flanking region of the apelin receptor gene (<i>APLNR</i>) was shown to be significantly associated with stroke in the Japanese population. However, the association required validation in other ethnicities. To validate the genetic relationship between <i>APLNR</i> and ischemic stroke in the Chinese Han population, we genotyped rs9943582 in a case-control population containing 1,158 ischemic stroke patients and 1,265 common controls enrolled from the GeneID database, and performed a genetic association study. We detected no allelic or genot","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2025-04-27T03:03:58.855Z","creation":"2019-03-27T03:05:55Z"},"accession":"S-EPMC5746099","cross_references":{"pubmed":["29296197"],"doi":["10.18632/oncotarget.22588"]}}