biostudies-literatureUnknown8(64)Wang PStroke is one of the most common causes of death worldwide. Genetic risk factors have been found to play important roles in the pathology of ischemic stroke. In a previous genome-wide association study, a functional variant (rs9943582, -154G/A) in the 5' flanking region of the apelin receptor gene (<i>APLNR</i>) was shown to be significantly associated with stroke in the Japanese population. However, the association required validation in other ethnicities. To validate the genetic relationship between <i>APLNR</i> and ischemic stroke in the Chinese Han population, we genotyped rs9943582 in a case-control population containing 1,158 ischemic stroke patients and 1,265 common controls enrolled from the GeneID database, and performed a genetic association study. We detected no allelic or genotOncotarget107678-107684https://www.ebi.ac.uk/biostudies/studies/S-EPMC5746099biostudies-literatureLack of association between the <i>APLNR</i> variant rs9943582 with ischemic stroke in the Chinese Han GeneID population.PMC5746099Wang PXiong LLi SWang BWang CWang QKXu CQTu XfalseLack of association between the <i>APLNR</i> variant rs9943582 with ischemic stroke in the Chinese Han GeneID population.Stroke is one of the most common causes of death worldwide. Genetic risk factors have been found to play important roles in the pathology of ischemic stroke. In a previous genome-wide association study, a functional variant (rs9943582, -154G/A) in the 5' flanking region of the apelin receptor gene (<i>APLNR</i>) was shown to be significantly associated with stroke in the Japanese population. However, the association required validation in other ethnicities. To validate the genetic relationship between <i>APLNR</i> and ischemic stroke in the Chinese Han population, we genotyped rs9943582 in a case-control population containing 1,158 ischemic stroke patients and 1,265 common controls enrolled from the GeneID database, and performed a genetic association study. We detected no allelic or genot2017-01-01T00:00:00Z2017 Dec2025-04-27T03:03:58.855Z2019-03-27T03:05:55ZS-EPMC57460992929619710.18632/oncotarget.22588